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Position Summary

This position will focus applying new and emerging tools such as single-cell sequencing, bulk RNA sequencing, and metabolomics, as well as publicly deposited big data, to characterize the mechanisms of AhR-mediated hepatic oxidative stress and the progression from steatohepatitis to hepatocellular carcinoma. In vivo and in vitro mouse and human models are also used to study the effects of TCDD and related AhR ligands on hepatic gene expression, metabolic flux, oxidative stress, and immune surveillance. The selected candidate will be expected to conduct research as part of a larger team, supervise/train undergraduate and graduate students, prepare research manuscripts, and present their results at scientific meetings. For more information, please visit the Zacharewski lab website http://dbzach.fst.msu.edu/.

Equal Employment Opportunity Statement

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, citizenship, age, disability or protected veteran status.

Required Degree

Doctorate -Biochemistry, Molecular Biology, Toxicology or a related field.

Minimum Requirements

• Demonstrated experience with basic molecular biology techniques (e.g. DNA/RNA/Protein extractions, qRT-PCR, westerns/capillary electrophoresis)
• Evidence of research productivity as determined by their publication record
• Excellent written and oral communication skills

Desired Qualifications

Preference will be given to candidates with experience in the following areas:

• Animal husbandry and necropsy
• Primary hepatocyte extractions and cell culture
• High throughput sequencing (RNA-Seq, ChIP-Seq, and/or Metagenomics)
• Mass spectrometry, metabolomics, and flux analysis
• Flow cytometry
• Histopathology
• Bioinformatics and basic programming skills

Required Application Materials

Cover letter outlining qualifications and research experience

Curriculum vitae/resume

Contact information for two or more references

Together-we-will Statement

Special Instructions

For more information, please visit our lab website at: http://dbzach.fst.msu.edu/

Review of Applications Begins On

03/31/2022

Website

http://dbzach.fst.msu.edu/

MSU Statement

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About Michigan State University

Spartans work every day to advance the common good in uncommon ways.Together, we tackle some of the world?s toughest problems to find solutions that make life better?from alternative energy to better food safety to breakthrough medical and environmental applications achieved through rare isotope research.We teach. We explore and we discover. We collaborate and lead. We innovate, inspire, and empower. We achieve our potential and create circumstances that help our students and others achieve theirs.We're good at it, and we've been at it for more than 150 years.The nation?s pioneer land-grant university, MSU began as a bold experiment that democratized higher education and helped bring science and innovation into everyday life. The revolutionary concept became a model for the nation.Today, MSU is one of the top research universities in the world?on one of the biggest, greenest campuses in the nation. Home to nationally ranked and recognized academic, residential college, and service-learning programs, we?re a diverse community of dedicated students and scholars, athletes and artists, scientists and leaders.In ways both practical and profound, we work to create a stronger, more sustainable, and more hopeful future for all.

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