This position will focus applying new and emerging tools such as single-cell sequencing, bulk RNA sequencing, and metabolomics, as well as publicly deposited big data, to characterize the mechanisms of AhR-mediated hepatic oxidative stress and the progression from steatohepatitis to hepatocellular carcinoma. In vivo and in vitro mouse and human models are also used to study the effects of TCDD and related AhR ligands on hepatic gene expression, metabolic flux, oxidative stress, and immune surveillance. The selected candidate will be expected to conduct research as part of a larger team, supervise/train undergraduate and graduate students, prepare research manuscripts, and present their results at scientific meetings. For more information, please visit the Zacharewski lab website http://dbzach.fst.msu.edu/.
Equal Employment Opportunity Statement
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, citizenship, age, disability or protected veteran status.
Doctorate -Biochemistry, Molecular Biology, Toxicology or a related field.
Evidence of research productivity as determined by their publication record
Excellent written and oral communication skills
Preference will be given to candidates with experience in the following areas:
Animal husbandry and necropsy
Primary hepatocyte extractions and cell culture
High throughput sequencing (RNA-Seq, ChIP-Seq, and/or Metagenomics)
Mass spectrometry, metabolomics, and flux analysis
Bioinformatics and basic programming skills
Required Application Materials
Cover letter outlining qualifications and research experience
Contact information for two or more references
The university is requiring all MSU students, faculty and staff to be vaccinated against COVID-19 with limited exceptions. Learn more at: https://msu.edu/together-we-will/
For more information, please visit our lab website at: http://dbzach.fst.msu.edu/
Review of Applications Begins On
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