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The Gradinaru Lab at the California Institute of Technology seeks highly motivated Research Scientists (2 openings), PhD level (postdoctoral experience a plus but not required), to serve as Directors for Experimental and Computational Protein Engineering and Discovery in the Beckman Institute Resource Center for CLARITY, Optogenetics and Vector Engineering (CLOVER Center: clover.caltech.edu).
The work will be fast paced, challenging and collaborative, and therefore requires that the candidate is well organized and has strong problem-solving, interpersonal and communication skills. It is essential that the applicant has hands-on experience with molecular cloning and cell culture. Additionally, the candidate must have experience with either animal models (i.e. rodent and/or NHP models) or computational protein engineering (i.e. structure prediction and protein design). The ideal candidate would also have experience with recombinant virus production, fluorescence microscopy, directed evolution, bioinformatics, and analysis of large datasets. Experience in experimental structure determination is a plus. Candidates need to have a doctoral degree in biological science and a strong record of productivity as evidenced by multiple publications, including as first and/or corresponding author. The position requires outstanding organizational skills, as well as experience in the managing of a life science laboratory and collaborations. The candidate will work independently under general guidance from the center PI, Prof. Gradinaru, and must exhibit strong problem-solving skills (e.g. be able to accurately recognize irregularities in experimental results and modify experiments as needed). Must be accurate, efficient, organized and keep detailed records. Strong written and verbal communication skills and the ability to work in a multi-disciplinary environment are required. Two positions, available immediately. Competitive pay and benefits, based on experience level.
Essential Job Duties
Protein engineering and discovery for specific target engagement using experimental and computational methods. The position will be leveraging our directed evolution and high throughput selection technologies, as well as previously identified AAV gene transfer vehicles that transduce, via the vasculature, the central and peripheral nervous systems and other important targets (e.g., heart, muscle), to discover novel cell-entry pathways. In addition, the position will be engineering new AAV variants and other molecular binders against defined targets.
The position will also be responsible for:
Preparing annual reports.
Grant writing - individual or collaboratively.
Guide external collaborators.
Present findings at group meetings and participate in lab discussions.
Work closely with the PI and other laboratory staff to adapt methodology to fit research requirements and ensure that research timelines are kept on track.
Keep careful records.
Train laboratory personnel and help with daily operations for smooth functioning.
Other duties as assigned.
Doctoral degree in biology, bioengineering, or a related field.
We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law.
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