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Details
Posted: 09-Mar-23
Location: Pasadena, California
Salary: Open
Internal Number: 3989421
Caltech
Exempt Overtime Eligible: Exempt
Benefits Eligible: Benefit Based
Caltech is a world-renowned science and engineering institute that marshals some of the world's brightest minds and most innovative tools to address fundamental scientific questions. We thrive on finding and cultivating talented people who are passionate about what they do. Join us and be a part of the diverse Caltech community.
Job Summary
The Gradinaru Lab at the California Institute of Technology seeks highly motivated Research Scientists (2 openings), PhD level (postdoctoral experience a plus but not required), to serve as Directors for Experimental and Computational Protein Engineering and Discovery in the Beckman Institute Resource Center for CLARITY, Optogenetics and Vector Engineering (CLOVER Center: clover.caltech.edu).
The work will be fast paced, challenging and collaborative, and therefore requires that the candidate is well organized and has strong problem-solving, interpersonal and communication skills. It is essential that the applicant has hands-on experience with molecular cloning and cell culture. Additionally, the candidate must have experience with either animal models (i.e. rodent and/or NHP models) or computational protein engineering (i.e. structure prediction and protein design). The ideal candidate would also have experience with recombinant virus production, fluorescence microscopy, directed evolution, bioinformatics, and analysis of large datasets. Experience in experimental structure determination is a plus. Candidates need to have a doctoral degree in biological science and a strong record of productivity as evidenced by multiple publications, including as first and/or corresponding author. The position requires outstanding organizational skills, as well as experience in the managing of a life science laboratory and collaborations. The candidate will work independently under general guidance from the center PI, Prof. Gradinaru, and must exhibit strong problem-solving skills (e.g. be able to accurately recognize irregularities in experimental results and modify experiments as needed). Must be accurate, efficient, organized and keep detailed records. Strong written and verbal communication skills and the ability to work in a multi-disciplinary environment are required. Two positions, available immediately. Competitive pay and benefits, based on experience level.
Essential Job Duties
Core Responsibility:
- Protein engineering and discovery for specific target engagement using experimental and computational methods. The position will be leveraging our directed evolution and high throughput selection technologies, as well as previously identified AAV gene transfer vehicles that transduce, via the vasculature, the central and peripheral nervous systems and other important targets (e.g., heart, muscle), to discover novel cell-entry pathways. In addition, the position will be engineering new AAV variants and other molecular binders against defined targets.
The position will also be responsible for:
- Preparing annual reports.
- Grant writing - individual or collaboratively.
- Guide external collaborators.
- Travel occasionally.
- Prepare publications.
- Present findings at group meetings and participate in lab discussions.
- Work closely with the PI and other laboratory staff to adapt methodology to fit research requirements and ensure that research timelines are kept on track.
- Keep careful records.
- Train laboratory personnel and help with daily operations for smooth functioning.
- Other duties as assigned.
Basic Qualifications
- Doctoral degree in biology, bioengineering, or a related field.
- Prior hands-on experience with molecular cloning, DNA/RNA isolation, mammalian tissue/cell culture, qPCR, transfections.
- DNA and virus library preparation, tittering and functional evaluation of vectors in vitro and in vivo.
- Cell culture for recombinant AAV and possibly lentivirus production and validation.
- In vivo vector administration, tissue processing, DNA/RNA isolation, immunohistochemistry, and microscopy.
- Working knowledge of sequence analysis tools such as BLAST, SnapGene/DNA Star/Vector NTI and primer design software.
- For the experiment-focused position, must have prior experience with mouse models and NHP models.
- For the computation-focused position, must have prior experience with computational protein structure prediction (by for example AlphaFold2) and protein design (by for example Rosetta or ProteinMPNN).
- Must be self-motivated and organized.
- Must have excellent communication and interpersonal skills - the position requires a coordinated effort within and across laboratories.
- Excellent communication skills (writing and verbal) and the ability to interact professionally with students and all levels of staff as well as with external collaborators.
- Ability to handle a variety of tasks simultaneously.
- Ability to resolve technical problems and adapt easily to changing needs and priorities.
- Must possess a high level of initiative.
Preferred Qualifications
- Experience working with recombinant viral vectors under BSL2 conditions.
- Hands on experience with fluorescence and confocal microscopy.
- Stereotaxic injections.
- Experience with immunohistochemistry, in situ hybridization.
- Experience with bioinformatics and analysis of next generation sequencing datasets.
- Familiarity with high throughput screens/selections, DNA library design, and directed evolution.
- Data Science.
- Experimental structure determination.
- Excellent organization, time management and project management skills.
Required Documents
- Resume
To be considered for this position please visit our web site and apply on line at the following link: https://hr.caltech.edu/work/job_openings
We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law.
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The California Institute of Technology (Caltech) is a world-renowned science and engineering research and education institution, where extraordinary faculty and students seek answers to complex questions, discover new knowledge, lead innovation, and transform our future.
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