A postdoctoral position in population genomics and evolutionary medicine is available immediately in the laboratory of Dr. PingHsun Hsieh in the Department of Genetics, Cell Biology, and Development (GCD) at the University of Minnesota, Twin Cities, MN. We are looking for a highly motivated and creative individual to leverage large datasets of long- and short-read genomes to investigate the full spectrum of human genetic diversity in relation to their evolutionary and functional consequences. Our lab specializes in understanding the biological and evolutionary role of structural variants (SVs) that remain largely unexplored in traditional human genetic studies.
The specific research project will be tailored to the interests of the individual, but we are particularly interested in (i) empirical and theoretical studies of how natural selection and demography shapes the genetic variation patterns in extant and archaic humans, (ii) studying structural mutations that have functional implications in adaptations and diseases, (iii) identifying novel eQTL and phenotype associations using multi-omics and large BioBank data, and (iv) the inference of fitness effects for different mutational classes (e.g. single-nucleotide variants vs. structural variants).
GCD is a vibrant, multi-disciplinary department, spanning the Medical School and College of Biological Sciences, with outstanding faculty expertise in genomics, bioengineering, cellular biophysics, and developmental biology. The successful candidate will have the opportunity to interact with many outstanding research groups in computational, evolutionary, and functional genomics across the Twin Cities campus, including Frank Albert, Yaniv Brandvain, Xiao Dong, Ched Myers, Maria Nieves-ColÃ³n, Anna Selmercki, and Arslan Zaidi. The beautiful Twin-Cities of Minneapolis and Saint Paul are a central hub for many biotech and bio-pharmaceutical companies and have close connections with the Mayo Clinic in Rochester, MN.
Job Duties: 70%: Primary research activities relevant to projects 10%: Preparation for manuscripts and oral presentations (e.g., departmental seminars and conference talks) 10%: Supervision and training of students and technical staff in the lab 10%: Professional development, such as applications for extramural funding and awards
Restrictions: Limited to a period of three years up to five, depending on training needs. The individual may be immediately post-degree or returning for additional training, updating, and retooling. Limited to fields for which post-degree training is necessary for career entry. Post-doctoral associates cannot be appointed on sponsored institutional training grants, sponsored individual fellowship or training awards. Post-doctoral associates are University of Minnesota employees. They are receiving additional training while also performing services for the University, for which they are compensated.
Note: These are not positions to which permanent residency can be granted for international appointees.
Required Qualifications: Applicants must have a Ph.D. or equivalent degree in the field of Population Genetics, Computational Biology, Statistics, Biostatistics, Computer Science, or other disciplines with strong quantitative backgrounds and strong programming skills.
Preferred Qualifications: Experience in population and statistical genetics analyses and working with large sequencing data sets are highly desired. The candidate must be highly motivated and independent with strong writing and communication skills.
The University of Minnesota, founded in the belief that all people are enriched by understanding, is dedicated to the advancement of learning and the search for truth; to the sharing of this knowledge through education for a diverse community; and to the application of this knowledge to benefit the people of the state, the nation, and the world.