Postdoctoral Fellowship in Alzheimer’s Disease Genetics
Michael D. Greicius
Location: Palo Alto, California
Type: Full Time
Years of Experience:
Less than 2
The Greicius Lab at Stanford University has a two-year postdoctoral position available in the genetics of Alzheimer’s disease and related disorders (ADRD). The Greicius lab studies ADRD using a combination of genetics, transcriptomics, proteomics, and neuroimaging methods. Our goal is to identify and characterize novel genetic variants that contribute to AD pathogenesis. Much of our research is focused on subjects with extreme neurodegenerative phenotypes, such as patients with early-onset AD or people who remain cognitively healthy at advanced ages despite carrying 1 or 2 copies of the high-risk APOE4 genetic variant.
The fellow will work closely with the PI, Dr. Michael Greicius, to develop and apply novel genetics approaches, with a focus on long-read sequencing, to the study of ADRD. The fellow will undertake a multimodal approach to the analysis of previously acquired GWAS, whole-exome, whole-genome, and gene expression datasets from a number of sources including ADNI, UK Biobank, and dbGaP, among others. The fellow will also help design and carry out new long-read sequencing studies in extreme ADRD phenotypes.
Substantial experience with GWAS, next-generation sequencing, gene expression, and proteomics is required
The ideal candidate will have expertise in genetics and a record of innovative research
We are particularly interested in candidates who think creatively, work hard, and write well
Knowledge of basic programming (i.e. Python, R) and the UNIX environment is ideal but not required
Dr. Greicius is the Iqbal Farrukh and Asad Jamal Professor in the Department of Neurology and Neurological Sciences at the Stanford University School of Medicine. He attended medical school at the Columbia University College of Physicians and Surgeons, did his neurology residency at the Harvard Partners program, and completed a behavioral neurology fellowship at UCSF. He first came to Stanford in 2000 as a postdoctoral fellow and joined the faculty in 2007. Dr. Greicius is currently the director of the Stanford Center for Memory Disorders and leads a research team studying the genetics of Alzheimer’s disease. Current efforts in the Greicius lab are focused on identifying novel genetic variants in two groups of subjects: healthy older people carrying the high risk APOE4 genetic variant and early age-at-onset Alzheimer’s patients who do not carry the high risk APOE4 genetic variant. The goal is to identify rare but powerful genetic mutations that either protect against or cause Alzheimer’s disease, respectively in these two groups. These genetic variants will then be characterized in detail to understand how they impact disease risk and how their related molecular pathways can be targeted for novel drug development.