Postdoctoral Scholar University of California Los Angeles
Requisition Number: JPF07980
Position: Postdoctoral fellow position in functional genomics of neuronal-glial mechanism and drug targets for neurodegenerative dementias. Rexach Lab, UCLA Neurology, Neurogenetics, Human Genetics.
Job Description: Seeking an outstanding applicant with strong research track-record for a competitive post-doctoral fellowship in functional genomics of neurodegenerative disease in the Rexach Lab in the UCLA department of Neurology and Human Genetics. The Rexach group uses integrative multiomics analysis, including single nuclear ATAC and RNA sequencing, to identify glial and immune-related drivers of neurodegenerative dementias, and then studies their function in disease model systems, including human iPSC-derived spheroids. The goal of this work is to identify and validate new therapeutic targets for neurodegenerative dementias, including Alzheimer's disease and related disorders, none of which have effective cures or treatments. This fellow would lead a single-cell and integrative bioinformatics study to identify both disorder-specific and disorder-convergent glial drivers and mechanisms of neurodegeneration, and complete functional validation and drug target identification using stem cell-derived models.
Requirements: The candidate will have a Ph.D. and/or M.D. degree.
Job Duties: Bioinformatics analyses of single nuclear RNA and ATAC sequencing data, multi-omics integration, network-based driver analysis, and genomic analyses. Design and execute functional validation experiments using human stem cell-derived neuronal-glial models. Prepare high-quality manuscripts to report research findings. Present at national and international meetings. Fully participate in research group meetings and activities. Participate in training junior students and colleagues within the Rexach lab. Excellent coordination and communication with collaborators. Data management, accountability, and post-publication code and data sharing.
Skills, Knowledge, and Abilities needed for the position: Proficiency in utilizing bioinformatics codes, packages and resources in R is required. Ability to code in R and/or Python are preferred. Experience in basic statistics in required. Experience in advanced statistics for omics research is preferred. Experience in transcriptomics, genomics, proteomics, or related analyses, are preferred. Experience in designing, executing and publishing scientific research is required. Interest and experience with methods development is preferred. Experience in writing first-author scientific manuscripts is required. Strong desire to learn, innovate, discover and collaborate are required. Respect for all colleagues and community is expected and required. Effective January 1, 2023, California Senate Bill 1162 (SB 1162) requires employers to disclose pay scales on all position postings. This law applies to all academic recruitments and positions.
Please submit the following to be considered for candidacy: Curriculum Vitae, Statement of Research , Contributions to diversity, and 2 references Please be advised that the final candidate recommended for hire into a critical (or otherwise designated) position will be required to successfully complete a background investigation. Any convictions will be evaluated to determine if they directly relate to the responsibilities and requirements of the position. Having a conviction history will not automatically disqualify an applicant from being considered for employment.
The offer of this position is contingent on the successful completion of a background check prior to your first day of employment and evidence of authorization to work in the United States. Also by accepting this offer you are acknowledging compliance with UCLA Health policy by receiving your influenza vaccination prior to your start date. If you are in agreement with the terms and conditions of this offer, please sign and return the enclosed copy of this letter. Feel free to contact Davis D. del Pino at 310-206-6567 to discuss any questions you may have regarding employment.
As a condition of employment, you will be required to comply with the University of California SARS-CoV-2 (COVID-19) Vaccination Program Policy. All Covered Individuals under the policy must provide proof of Full Vaccination or, if applicable, submit a request for Exception (based on Medical Exemption, Disability, and/or Religious Objection) or Deferral (based on pregnancy) no later than the applicable deadline. For new University of California employees, the applicable deadline is eight weeks after their first date of employment. The University of California is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy. UC Nondiscrimination & Affirmative Action Policy.
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The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy, see: UC Nondiscrimination & Affirmative Action Policy, https://policy.ucop.edu/doc/4000376/DiscHarassAffirmAction jeid-aa8ae3658a089b4f8c91a31edc186d9f
UCLA is known worldwide for the breadth and quality of its academic, research, health care, cultural, continuing education and athletic programs. UCLA offers undergraduate degrees in more than 127 majors and graduate degrees in 198 program areas. UCLA has 11 highly regarded professional schools. Eight are ranked among the nation's top 15 in their field by U.S. News & World Report. UCLA is consistently among the most popular campus in the nation for undergraduate applicants. The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to age, race, color, religion, sex, national origin, disability, or protected veteran status. Benefits:UCLA offers a comprehensive benefits package, including an average of three weeks' vacation per year; an average of 12 days per year sick leave; 13 paid holidays per year; health, dental and optical benefits; life insurance; disability insurance; the University of California Retirement Plan with 5 year vesting and various voluntary UC Savings Plans. There are also special programs and privileges available, such as accessibility to cultural and recreational programs, athletic events, and the University Credit Union.