Career Center

Overview

Fred Hutchinson Cancer Center is an independent, nonprofit organization providing adult cancer treatment and groundbreaking research focused on cancer and infectious diseases. Based in Seattle, Fred Hutch is the only National Cancer Institute-designated cancer center in Washington.

With a track record of global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy and COVID-19 vaccines, Fred Hutch has earned a reputation as one of the world's leading cancer, infectious disease and biomedical research centers. Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures to the world's deadliest diseases and make life beyond cancer a reality.

At Fred Hutch we value collaboration, compassion, determination, excellence, innovation, integrity and respect. These values are grounded in and expressed through the principles of diversity, equity and inclusion. Our mission is directly tied to the humanity, dignity and inherent value of each employee, patient, community member and supporter. Our commitment to learning across our differences and similarities make us stronger. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an anti-racist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, anti-racism and inclusion.

The Meshinchi Lab (Clinical Research Division) is seeking a Bioinformatics Analyst II. This lab focuses on finding new therapeutic treatments for pediatric and young adults with acute myeloid leukemia.

The successful applicant will help analyze our large, complex genomic datasets. Since 2009, the Meshinchi (Soheil Meshinchi, MD, PhD) lab has developed the largest transcriptomic, genomic and methylomic database of pediatric AML worldwide. Using these data, the lab is focused on finding novel treatments (matching expressed protein targets to new therapies) and identifying biomarkers for monitoring patients' disease. Fred Hutch provides a highly interactive and supportive environment to grow and develop their career; it consistently ranks in the top 20 best places to work for postdocs, as surveyed by The Scientist.

Responsibilities

Responsibilities will include a variety of analysis methodologies and data file storage/organizational duties. The following are typical tasks the successful applicant will perform:

• Analyze large sequence datasets from diverse workflows including exome capture, RNA-seq, single cell sequencing, CUT&RUN, ChIP-seq, ATAC-seq, and CRISPR screens.
• Work with Hutch scientists to refine computational research questions and develop analytical processes that can be applied to these genomic datasets.
• Consult with researchers on sound experimental design.
• Identify appropriate bioinformatics tools to meet the needs of proposed projects.
• Partner with researchers who are developing novel assays to design appropriate processing and analysis workflows.
• Review current literature to identify and adopt software and methodologies, making new analysis capabilities available to the Hutch community.
• Provide figures and written sections to document methods and results for manuscripts, presentations, and grant applications.
• Collaborate with colleagues in the Genomics Shared Resource and the Hutch Data Core to ensure the integrity and consistency of primary data, to track experimental methods and metadata, to define standardized analysis pipelines, and to provide training and support as users analyze and interpret results.

Qualifications

Minimum Qualifications:

• Master's degree in bioinformatics, computational biology, genetics, or related field with at least three years' direct experience in computational analysis of large sequence-based molecular data sets
• Direct experience must include best-practice germline & somatic variant calling from exome capture data, analysis of bulk RNA-seq data with multiple contrasts, analysis of multimodal single-cell profiling data, epigenetic profiling, gene set enrichment, and integration of data across multiple modalities (e.g., epigenetic profiling and RNA-seq).
• Effective use of shell scripting and significant fluency in R and Python 3 are essential.
• Facility with commonly used Bioconductor packages, ggplot, tidyverse etc. Ability to generate and customize common data visualizations (PCA plots, volcano plots, Circos plots, etc).
• Familiarity with workflow and scheduling software (e.g. Slurm).
• Excellent written and verbal communication skills are absolutely required.

Preferred Qualifications:

• Proficiency in R (preferably) or python
• Ability to learn new tools and content quickly and independently
• Strong oral and communication skills
• Willing to work onsite most days (some flexibility in remote work)

Fred Hutchinson Cancer Center has a mandatory COVID-19 vaccine requirement, with exceptions only for approved medical or religious accommodations. As a condition of employment, newly hired employees must, prior to their first day of employment: Provide proof of being fully vaccinated against COVID-19 ; ORInitiate the accommodations process to request a religious or medical accommodation (medical accommodations require a healthcare provider's certification).

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and antiracism in your career or that will be made through your work at Fred Hutch is requested of all finalists.

The hourly pay range for this position is from $35.75 to $53.62 and pay offered will be based on experience and qualifications.

Fred Hutchinson Cancer Center offers employees a comprehensive benefits package designed to enhance health, well-being, and financial security. Benefits include medical/vision, dental, flexible spending accounts, life, disability, retirement, family life support, employee assistance program, onsite health clinic, tuition reimbursement, paid vacation (12-22 days per year), paid sick leave (12-25 days per year), paid holidays (13 days per year), paid parental leave (up to 4 weeks), and partially paid sabbatical leave (up to 6 months).

Our Commitment to Diversity

We are proud to be an Equal Employment Opportunity (EEO) and Vietnam Era Veterans Readjustment Assistance Act (VEVRAA) Employer. We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability (physical or mental), marital or veteran status, genetic information, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at hrops@fredhutch.org or by calling 206-667-4700.