Postdoctoral Research Fellow/Associate - Genetics/Genomics
Cincinnati Children's Hospital Medical Center
Location: Cincinnati, Ohio
Academic / Research
Internal Number: 138838
The Slavotinek lab is seeking to add a postdoctoral research fellow/associate to the team. The research program in the Slavotinek laboratory is focused on investigating the genetic causes of birth defects and rare syndromes and diseases. We use exome sequencing and whole genome sequencing to investigate the genetic etiology of developmental eye defects in patients with absent eyes (anophthalmia), small eyes (microphthalmia) and early onset of cataracts. Gene variants are further studied using in vitro assays and zebrafish as an animal model system, utilizing CRISPR/Cas9 for gene editing to model loss of function variants and CRISPR/Cas9 with homology directed repair to create specific sequence variants and to repair deleterious sequence variants. We also use 'bulk' RNA-Seq and single cell RNA-Seq to study alterations in downstream gene expression.
MAJOR DUTIES AND RESPONSIBILITIES:
Design, execute, and record laboratory experiments, and analyze the data.
Research and improve current methods and evaluate innovative techniques. Implement this knowledge in the Division/Department.
Present research at laboratory meetings, journal clubs, seminars, and meetings.
Draft, write, and edit scientific reports, papers, journal articles, abstracts, and grants.
Maintain currency in field through continuing education, literature, and seminars.
Attend required Cincinnati Children's training sessions and ensure regulatory compliance with all policies and procedures.
Perform other duties as assigned.
Cincinnati Children's Research and Training at a Glance
Among the top in NIH funding for pediatric research institutions
Over 1.4 million square feet of research laboratory space
900+ scientists conducting basic, translational, and clinical research
Over 2000 publications annually in top-tier journals
Access to Employee Resource Groups and Mentorship programs
Postdocs have gone on to careers in academia, biotech, pharma, teaching etc.
Ph.D. in related discipline, MD, or equivalent required.
For Research Associate:
3 - 5 years of work experience in a related job discipline
In addition to a PhD or MD, proficiency in bioinformatics and biostatistical analysis, standard molecular biology and biochemistry methods is required. Experience in zebrafish model systems, CRISPR/Cas9 and RNA-Seq methodologies and confocal microscopy is also preferred.
REQUIRED SKILLS: Excellent written, verbal, and interpersonal communication skills. Demonstrate attention to detail, strong organizational skills, supervisory ability, and an innovative approach to experimental design. Computer literate and working knowledge of software applications (word processing, spreadsheet, and database). Analytical ability sufficient to compare data; mathematical ability sufficient to perform algebraic calculations and statistical analysis. Ability to synthesize information and to create and deal with new situations by applying past experiences. Expressed willingness to teach others and share results. Capable of meeting time demands necessary to execute experiments.
Cincinnati Children's is proud to be an Equal Opportunity Employer that values and treasures Diversity, Equity, and Inclusion. We are committed to creating an environment of dignity and respect for all our employees, patients, and families (EEO/AA).
About Cincinnati Children's Hospital Medical Center
At Cincinnati Children’s, we come to work with one goal: to make children’s health better. We believe in a team approach, both in caring for patients and their families, and in advancing science and discovery. We strive to do better, and find energy and inspiration in our shared purpose. If you want to be the best you can be, you can do it at Cincinnati Children’s.