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Job Summary
The staff scientist will lead two established NIH-funded projects. One focuses on the biology of an Inflammatory Bowel Disease risk allele C1ORF106 (INAVA) in intestinal epithelia and will address how the protein acts after it releases from the membrane to form bio molecular condensates involved in regulating cellular proteostasis. The second project focuses on an epithelial membrane polarity complex and how it acts in a novel mechanism of cell-autonomous host defense we recently discovered. Both projects will utilize infrastructure established in the GI Cell Biology division, and throughout the Longwood Medical Area.

Staff Scientist Job Summary
Working with the Principal Investigator (PI), provides scientific expertise and leads and guides a research team in the development of original scientific research at BCH. Conducts autonomous work and contributes to the development of research projects' strategy and outcome. Collaborates with PI in preparing scientific papers as needed. May participate in writing of grant proposals, technical meetings and symposia.
This role may manage and/or advise lab personnel and have latitude in decision-making, including a role in management of departmental or institutional cores. The individual remains under the supervision of a PI and is generally not expected to submit grants as a PI, except those grants that might not require faculty rank for submission. This is not considered a faculty level position at BCH or HMS.

Principle Duties and Responsibilities:

• Works with PI in determining original scientific research projects' goals, methodologies and deliverables.
• Leads and implements research under the PI's guidance.
• Guides and/or supervises research lab personnel at the direction of the faculty PI.
• Participates in writing of grant proposals, planning and implementing technical meetings and symposia.
• Collaborates with PI in preparing scientific papers, presentations as needed.

Minimum Education and Experience:
A Master level degree, with at least 7 years original and relevant research of experience.

Knowledge and Skills:

• Must have analytical development and demonstrated success in working on complex novel problems.
• Expertise in murine animal models, computational bioinformatics, protein chemistry and high-throughput screening is required.
• The candidate must be able to work independently, problem solve and be outgoing in the laboratory environment.

Boston Children's Hospital offers competitive compensation and unmatched benefits including flexible schedules, affordable health, vision and dental insurance, child care and student loan subsidies, generous levels of time off, 403(b) Retirement Savings plan, Pension, Tuition and certain License and Certification Reimbursement, cell phone plan discounts and discounted rates on T-passes. Experience the benefits of passion and teamwork.

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