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Posted: 03-Dec-22
Location: Ann Arbor, Michigan
Salary: Open
Internal Number: 227598
A cover letter is required for consideration for this position and should be attached as the first page of your resume. The cover letter should address your specific interest in the position and outline skills and experience that directly relate to this position.
The laboratory of Stephen Weiss, at the Life Sciences Institute, is looking for a Research Investigator to oversee a research project to study the role of a series of transcription factors in the regulation of cancer stem cell generation in vitro and in vivo. Major goals include the generation of cancer stem cell lines using genome editing, the characterization of novel regulators of stem cell formation and function using a combination of cell and molecular biology and transgenic mouse engineering. These studies will require considerable expertise and research experiences in cell and molecular biology techniques, including confocal microscopy, real-time quantitative PCR (qRT-PCR), cloning, gene expression and protein analyses and functional assays for characterizing cancer stem cell function. In addition to planning and performing experiments, you will oversee research performed by students and research technicians. You will report directly to Dr. Stephen Weiss.
Experimental responsibilities will include:
- Design experiments in collaboration with others
- Design constructs to produce proteins in forms suited for their specific downstream use
- Use modern cloning methodologies to clone multiple genes and fragments into the appropriate bacterial, baculovirus and mammalian expression vectors
- Maintain mammalian cell cultures and stocks
- Maintain and dispense from mammalian vector libraries
- Use CRISPR/Cas9 – based technologies
- Manage transgenic mouse colony
- Perform quantitative analyses and communicate findings through reports and summaries
- Solve experimental problems that arise in any of the responsibilities
Non-experimental responsibilities will include:
- Provide consultation and advice to lab members in areas of expertise
- Maintain clear laboratory notebooks
- Provide detailed documentation so experiments can be replicated
- Follow laboratory best practices for safety and quality
- Help manage projects
- Assist PI in preparing manuscripts and grants
- Ph.D. in molecular biology, cell biology, biochemistry, biophysics, or related discipline
- Minimum 3 years experience of post-doctoral work
- Minimum 5 years experience in cell and molecular biology techniques, including confocal microscopy, real-time quantitative PCR (qRT-PCR), cloning, gene expression and protein analyses and functional assays for characterizing cancer stem cell function
- Minimum 3 years experience managing transgenic mouse colony
- Minimum 3 years experience with CRISPR/Cas9-based technologies
- Minimum 3 years experience mentoring students and research staff
- Strong publication record in relevant work
- Prior experience working in a collaborative environment
- Minimum 2 years experience characterizing mouse transgenic models
In addition to a career filled with purpose and opportunity, The University of Michigan offers a comprehensive benefits package to help you stay well, protect yourself and your family and plan for a secure future. Benefits include:
- Generous time off
- A retirement plan that provides two-for-one matching contributions
- Many choices for comprehensive health insurance
- Dental, Vision, and Legal Insurance
- Life insurance
- Long-term disability coverage
- Flexible spending accounts for healthcare and dependent care expenses
- Maternity and Parental Leave
The University of Michigan conducts background checks on all job candidates upon acceptance of a contingent offer and may use a third party administrator to conduct background checks. Background checks are performed in compliance with the Fair Credit Reporting Act.
Our mission at the Life Sciences Institute is to promote the understanding of the fundamental processes of life, and to develop new ideas to improve human health.
For additional information on the Life Sciences Institute, please go to: https://www.lsi.umich.edu/about.
For more information on the Weiss laboratory: https://www.lsi.umich.edu/science/our-labs/stephen-weiss-lab
Job openings are posted for a minimum of seven calendar days. The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled anytime after the minimum posting period has ended.
The University of Michigan is an equal opportunity/affirmative action employer.
U-M COVID-19 Vaccination Policy
COVID-19 vaccinations, including one booster when eligible, are required for all University of Michigan students, faculty and staff across all campuses, including Michigan Medicine. This includes those working remotely and temporary workers. More information on this new policy is available on the U-M Health Response website or the UM-Dearborn and UM-Flint websites.
