Senior Research Scientist, Epigenetics - Center for Epigenetics Research Memorial Sloan Kettering Cancer Center
Memorial Sloan-Kettering Cancer Center
Location: New York, New York
Internal Number: 63827
$74,263 - $110,000
At Memorial Sloan Kettering (MSK), we're not only changing the way we treat cancer, but also the way the world thinks about it. By working together and pushing forward with innovation and discovery, we're driving excellence and improving outcomes. We're treating cancer, one patient at a time. Join us and make a difference every day.
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The Center for Epigenetics Research is seeking a highly motivated and successful individual with a background in epigenetics and molecular biology. As a Senior Research Scientist within the Center for Epigenetics Research (https://www.mskcc.org/research-programs/epigenetics-research), for leading the technology development effort of the Innovation Laboratory. The core mission of this group is to develop new experimental methodologies in epigenetics research and implement these and existing technologies. The group will work in close collaboration with clinicians and scientists at MSK, as well the computational biology and genome analysis group in the Center for Epigenetics research. This position involves the oversight and training of laboratory staff at the M.S. and Ph.D. levels and requires the ability to define and articulate new research directions and experimental approaches. In addition to overseeing day-to-day operations in the laboratory, this role requires a broad base of technical knowledge regarding existing methods in epigenetics research as well as the ability to creatively invent and customize new ones. The senior research scientist will work closely with leadership, experimental and computational biologists, and technical staff in the Center.
Lead and manage laboratory staff
Interview, hire, orient, and train new laboratory staff
Delegate work to staff to meet center goals and requirements
Work with laboratory staff and the director to define and articulate research directions, new techniques, and laboratory procedures for the Innovation Lab
Attend management technique or other leadership classes as referred by supervisor
Evaluate and determine the benchmarking needed and the metrics required for building and monitoring the experimental procedures
As leader of the Innovation Lab, meet with other project leaders to design and execute project enhancements that allow for maximal integration of techniques and staff expertise
Assist in grant writing
Work with Lab Managers and Project Managers to determine the metrics needed to assess quality of and need for updating laboratory procedures
Work with the Computational group to synergize the experimental procedures with the computational analysis
Evaluate the novelty of newly designed methods regarding patentability and potential intellectual property
Ensure data migration occurs in an efficient and timely manner with regard to the needs of core members and collaborators
Aid in the development of the laboratory portion of chargeback for internal and external projects along with other center leadership and director
Implement and optimize commonly used methodologies for epigenetics research to address: gene expression (RNAseq, GRO-seq), histone modifications (ChlP-seq, native ChIP-seq, CUT&RUN, CUT&Tag), chromatin accessibility (ATAC-seq, MNase-seq), DNA methylation (bisulfite-seq, EM-seq), chromatin organization (HiC-techniques), and single cell approaches (SHARE-seq, Paired-tag, ...)
Provide consultation and guidance to research scientists and other members of the Center
Guide researchers in choosing the right method for addressing a specific question and train them in sample handling and experimental procedures
Assist collaborators with experimental protocols and development of those
The ideal candidate should have:
Doctorate/PhD (at least 3-4 years of experience at Postdoc level)
Extensive hands-on knowledge and experience with the most common high throughput epigenomics profiling techniques such as ChIP-seq, CUT&RUN, ATAC-seq, Bisulfite sequencing and others
Broad experience in molecular biology techniques
Excellent knowledge about epigenetics research
Strong analytical skills
Excellent communication skills, ability to work collaboratively and effectively
Skills in computational biology is a plus
Experience in mentoring and training is a big plus
If you have any questions about this job opportunity, please contact:
Pierre-Jacques Hamard, Ph.D.
Manager, Epigenetics Innovation Research Lab
Salary: $74,263 - $110,000
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As one of the world's premier cancer centers, Memorial Sloan-Kettering Cancer Center is committed to exceptional patient care, leading-edge research, and superb educational programs. The close collaboration between our physicians and scientists is one of our unique strengths, enabling us to provide patients with the best care available today as we work to discover more effective strategies to prevent, control, and ultimately cure cancer in the future. Our education programs train future physicians and scientists, and the knowledge and experience they gain at Memorial Sloan-Kettering has an impact on cancer treatment and the biomedical research agenda around the world.