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The Department of Medical and Molecular Genetics at Indiana University School of Medicine is seeking applicants at the post-doctoral level for the Post-Doctoral Clinical Genomic Scientist position.

Job Description

The successful candidates must have a Ph.D. degree with a strong research background in Molecular Genetics. The ideal postdoctoral candidate will analyze and interpret genetic sequence variation identified through diagnostic genetic testing or through research pipelines, primarily using Next Generation Sequencing (WES, WGS, and RNA-seq). In this role, the postdoctoral Clinical Genomics scientist will interpret clinical data, perform phenotype-driven genomic analyses, and maintain an internal database of curated genomics variants. Under the supervision of the URDC (Undiagnosed Rare Disease Clinic) directors, will assist with research projects that report new gene discovery, variant reclassification and lead or contribute to scientific publications.

The Undiagnosed and Rare Disease Clinic (URDC) was launched in January 2020. The URDC program combines the strengths of IU Health clinical care specialists and IU School of Medicine researchers. From the clinical side, specialists look through each patients' records, review the list of symptoms, and evaluate each patient when they arrive at the clinic. From the research side, specialists can reevaluate the raw data from a patient's whole exome sequencing test, which involves looking at exons, which are the pieces of an individual's DNA that provide instructions for making proteins. Researchers may also suggest whole genome sequencing to get a better understanding of genetic changes that may lead to health problems. This program is focused mainly on pediatrics, but URDC patients may be any age, from newborns to those with adult-onset disorders, who have likely been seen by multiple providers and had extensive testing done, but still haven't received conclusive results about their condition.

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