Career Center

Phatnani lab seeks an independent but team-oriented Post-doctoral Research Associate to generate multimodal omics data of gene and protein expression with spatial context, all at scale, over multiple tissue sections at a depth sufficient to permit identification of the rare and heterogeneous senescence cell population. S/he will assemble unified workflows for measuring gene expression, protein abundance, and aggregate cellular composition, utilizing leading-edge technologies that operate at cellular and subcellular resolution in situ, to map cell type-specific senescence markers in the brain, spinal cord, skin, and the relevant biofluids, cerebrospinal fluid (CSF) and blood, during aging.

Currently, our group received funding to engage in a ground breaking collaboration with multiple departments in which we use the integration of Spatial Transcriptomics (ST), single-nucleus RNA-seq (snRNA-seq) data, and Iterative Indirect Immunofluorescence Imaging (4i)-based proteomic profiling that will enable to generate maps of known and novel senescence-associated markers, senescent cells, and the effects of senescent cells on their surroundings in each tissue type across the human lifespan.

Responsibilities may include:

• Learn and Implement workflows for collecting spatially and integrating resolved data in all modalities of the central dogma using current state-of-the-art technologies;
• Develop new methods for collection of spatialy resolved, multi-modal data;
• Coordinate efforts across multiple cores/departments;
• Actively participate in the preparation of manuscripts for publication and present at scientific conferences;
• Assist in peer- and student-mentorship; and,
• Share expertise and provide training and guidance to group members as needed
• Assist with organization and logistics of the laboratory

Position Requirements

• A minimum of a Ph.D. in molecular biology, biochemistry, neurobiology or related discipline required;
• In-depth understanding of nucleic acid and protein biochemistry required;
• Prior experience with tissue handling, experimental biochemistry and molecular biology, imaging, and computational analysis are preferred, but exceptionally creative and driven scientists with an interest will be seriously considered;
• Strong oral and written communication, data documentation, and presentation skills required;
• Ability to handle multiple projects at the same time required; and,
• Excellent collaborative and interpersonal skills required.
   

Columbia University is an Equal Opportunity Employer / Disability / Veteran

Pay Transparency Disclosure

The salary of the finalist selected for this role will be set based on a variety of factors, including but not limited to departmental budgets, qualifications, experience, education, licenses, specialty, and training.  The above hiring range represents the University's good faith and reasonable estimate of the range of possible compensation at the time of posting.

About Columbia University

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