The Sims Lab in the Department of Systems Biology at Columbia University Irving Medical Center is seeking a Staff Associate II to provide computational biology and bioinformatics support to a large-scale immunological profiling project involving perturbation of live human tissues, single-cell genomics, and several other molecular profiling technologies. The effort will involve the development and application of platform technologies for analyzing vaccine responses as part of a team of investigators and researchers at Columbia. The Sims Lab has similar technology development efforts in cancer biology, and there will be opportunities to become involved in these projects as well.
Duties and Responsibilities:
Key responsibilities include the maintenance and implementation of computing pipelines for analyzing CITE-seq, single-cell RNA-seq, single-cell DNA-seq, single-cell ATAC-seq, and immune repertoire profiling data.
Research duties include managing data storage, data transfer, data sharing, data processing (i.e. demultiplexing and alignment of sequencing data), and downstream data analysis (i.e. unsupervised clustering, differential expression analysis, data visualization, data integration, statistical inference, classification).
Computational analysis will take advantage of a cloud computing infrastructure.
Related responsibilities include keeping detailed written and computer records of computational methods and presenting results to the principal investigator and other team members.
Bachelor's degree in biology, chemistry, physics, math, engineering, bioinformatics, computer science or a related field.
Experience with bioinformatic analysis of genomic and/or transcriptomic sequencing data.
Experience working with a Linux operating system.
Experience working with and fluency in at least one high-level programming language (e.g. Python, R, or similar).
Excellent communication skills and teamwork.
Strong creative thinking and problem-solving skills.
Graduate degree in biology, chemistry, physics, math, engineering, bioinformatics, computer science or a related field.
Columbia University is one of the world's most important centers of research and at the same time a distinctive and distinguished learning environment for undergraduates and graduate students in many scholarly and professional fields. The University recognizes the importance of its location in New York City and seeks to link its research and teaching to the vast resources of a great metropolis. It seeks to attract a diverse and international faculty and student body, to support research and teaching on global issues, and to create academic relationships with many countries and regions. It expects all areas of the university to advance knowledge and learning at the highest level and to convey the products of its efforts to the world.