This position assists with the technical aspects of studies and experiments, including documentation and preparation of materials.
The Greer lab is interested in how non-genetic information can be transmitted across generations and how non-genetic information regulates complex phenotypes. An increasing number of complex phenotypes, such as physical appearance, energy metabolism, psychological state, and longevity, have recently been shown to be regulated, in part, by epigenetic information. Epigenetics describes how gene expression changes occur without changes to the DNA sequence. Proteins, RNA molecules, or chemical modifications to histones or DNA can induce these epigenetic changes. How this information, which is not directly coded in our DNA, is passed from generation to generation is still unknown.
Understanding the molecular determinants of stable epigenetic memory will provide insight into how environmental changes can affect the health and lifespan of not only the individual who experiences them, but also of their progeny. Our goals are to identify epigenetic inheritance phenotypes and to elucidate the mechanisms behind their transmission across generations. We also aim to understand how epigenetic mis-regulation can cause developmental defects and disease.
In the Greer lab we use the nematode C. elegans, the social amoeba Dictyostelium, mice, and mammalian tissue culture systems to study how non-genetic information can be transmitted across generations as well as to understand the role of non-genetic information in regulating a variety of biological processes. We use a wide variety of genetic, biochemical, and molecular techniques to decipher these complex question. Some experiments would entail worm, Dictyostelium, or mouse husbandry, extracting gDNA and proteins from worm and tissue samples, running dot blots and Western blots, purifying proteins and testing their enzymatic activity. The Greer lab strives to be a place of fun, collegiality, and collaboration. While some research experience is a big plus it is not required.
This position works in a laboratory environment with potential exposure to biological and chemical hazards.Â The individual must be physically able to wear protective equipment and to provide standard care to research animals.
Demonstrated ability to work independently and communicate with laboratory staff and investigators.
Ability to maintain complete and organized records/reports.
Working knowledge of computer software and general lab equipment.
Bachelorâ™s degree and up to one year of experience in a laboratory setting or an equivalent combination of education and experience equaling four years.
$16.08 - $25.12 / HourlyThe salary range reflects base salaries paid for positions in a given job grade across the University. Individual rates within the range will be determined by factors including one's qualifications and performance, equity with others in the department, market rates for positions within the same grade and department budget.
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.
Washington University in St. Louis is committed to providing a comprehensive and competitive benefits package to our employees. Benefits eligibility is subject to employment status, full-time equivalent (FTE) workload, and weekly standard hours. Please visit our website at https://hr.wustl.edu/benefits/ to view a summary of benefits.
Washington University in St. Louis is committed to the principles and practices of equal employment opportunity and especially encourages applications by those from underrepresented groups. It is the Universityâ™s policy to provide equal opportunity and access to persons in all job titles without regard to race, ethnicity, color, national origin, age, religion, sex, sexual orientation, gender identity or expression, disability, protected veteran status, or genetic information.
Washington University is dedicated to building a diverse community of individuals who are committed to contributing to an inclusive environment â“ fostering respect for all and welcoming individuals from diverse backgrounds, experiences and perspectives. Individuals with a commitment to these values are encouraged to apply.
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