The Bolton Lab is seeking a postdoctoral researcher to advance research in cancer genomics, with a focus on acquired pre-leukemic mutations in the blood, clonal hematopoiesis. Our group has led some of the largest and most comprehensive studies of how environmental factors the evolution of clonal hematopoiesis and promotes its transformation to leukemia (Bolton, Nature Genetics 2020) and other outcomes (Bolton, Nature Communications 2021). This work has in turn informed clinical management guidelines for individuals with clonal hematopoiesis (Bolton, JCO, 2019; Steensma and Bolton, Blood 2020) and clinical trials lead by our group.
The postdoctoral researcher will lead projects to characterize the dynamics of clonal hematopoiesis and the progression to adverse health outcomes. Work will include analysis of targeted sequencing data, SNP array and RNA-Seq data (both bulk and single cell) for comprehensive characterization of genomic events. Opportunities are available to perform murine and in vitro modeling of clonal hematopoiesis and leukemia in collaboration with the Daniel Link and Matthew Water labs at Washington University. Depending on the interest of the researcher this could be the focus of the postdoctoral work. There will also be opportunities to develop additional independent projects with clinical collaborators at Washington University.
The postdoctoral researcher will have the opportunity to work within a team of scientists within and collaborating with the Bolton laboratory. In addition to high-quality research facilities, career and professional development training for postdoctoral researchers is provided through the Career Center, Teaching Center, Office of Postdoctoral Affairs, and campus groups.
Trains under the supervision of a faculty mentor including (but not limited to):
Manages their own project, which should lead to a first author publication.
Develops expertise in bioinformatics skills and if interested murine and in vivo modeling of clonal hematopoiesis.
Develops proficiency in career skills, including writing, public speaking, networking, and critical evaluation of scientific literature.
Presents scientific work both inside and outside the university with excellent oral communication skills.
Assists with grant preparation and reporting.
Prepares and submits papers on research with excellent writing skills.
Designs research experiments.
Evaluates research findings and reports results.
Conscientious discharge of research responsibilities.
Maintains conformity with ethical standards in research.
Maintains compliance with good laboratory practice including the maintenance of adequate research records.
Engages in open and timely discussion with mentor regarding possession or distribution of material, reagents, or records belonging to their laboratory and any proposed disclosure of findings or techniques privately or in publications.
Collegial conduct towards co-trainees, staff members and members of the research group.
Adheres to all applicable university policies, procedures and regulations.Â All data, research records and materials and other intellectual property generated in university laboratories remain the property of the university.
Ph.D., M.D. or equivalent terminal or doctoral degree.
Ph.D. in bioinformatics, statistics, mathematics, physics, or a related quantitative field, with previous experience in analysis of large-scale omics data; or a Ph.D in cancer biology or molecular genetics with an interest in further developing computational skills.
This position works in a laboratory environment with potential exposure to biological and chemical hazards.Â The individual must be physically able to wear protective equipment and to provide standard care to research animals.
Base pay is commensurate with experience.
Applicant Special Instructions
Please email CV, the names of two references, and a cover letter to Dr. Kelly Bolton at email@example.com.
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.
Washington University in St. Louis is committed to providing a comprehensive and competitive benefits package to our employees. Benefits eligibility is subject to employment status, full-time equivalent (FTE) workload, and weekly standard hours. Please visit our website at https://hr.wustl.edu/benefits/ to view a summary of benefits.
Washington University in St. Louis is committed to the principles and practices of equal employment opportunity and especially encourages applications by those from underrepresented groups. It is the Universityâ™s policy to provide equal opportunity and access to persons in all job titles without regard to race, ethnicity, color, national origin, age, religion, sex, sexual orientation, gender identity or expression, disability, protected veteran status, or genetic information.
Washington University is dedicated to building a diverse community of individuals who are committed to contributing to an inclusive environment â“ fostering respect for all and welcoming individuals from diverse backgrounds, experiences and perspectives. Individuals with a commitment to these values are encouraged to apply.
Washington University in St. Louis, a medium-sized, independent university, is dedicated to challenging its faculty and students alike to seek new knowledge and greater understanding of an ever-changing, multicultural world. The University offers more than 90 programs and almost 1,500 courses leading to bachelor's, master's and doctoral degrees in a broad spectrum of traditional and interdisciplinary fields, with additional opportunities for minor concentrations and individualized programs. The faculty is composed of scholars, scientists, artists and members of the learned professions. They serve society by teaching; by adding to the store of human art, creativity, understanding, and wisdom; and by providing direct services, such as health care.