The Reproductive Biology Hub Director will manage operations, facilities and employees of the ReproHub at the Buck Institute for Research on Aging in support of innovative research aimed at understanding the biological processes that underlie both reproductive age-related diseases and reproductive aging. The ReproHub is a core facility that provides experimental support and training for studies requiring expertise in reproductive biology. The ReproHub Director will provide intellectual and technical expertise on reproductive science, working collaboratively with scientific staff in labs at Buck and other institutions on research projects related to reproductive aging.
The Hub Director is a PhD scientist with extensive expertise in mammalian reproductive biology who can direct and execute sophisticated integrative projects in reproductive biology and aging, and analyze and interpret data. In addition to state-of-the-art instrumentation and fee-for-service assays utilizing rodent, primate, and human reproductive tissues, the Hub enables lab members to obtain training in the techniques necessary to carry out these experiments in their home labs. This knowledge transfer will be essential to bring in new researchers to tackle the problem of reproductive aging. The Hub Director will consult and advise on the level of access offered by the Hub on specific aspects of projects, through training on particular techniques and/or instruments available in the Hub, to complete molecular analyses from sample preparation to final data analysis and interpretation.
The qualified applicant will work closely with senior scientific staff in labs and with other Core Directors at Buck, and with scientists from other Institutions on research projects related to reproductive aging. This collaborative position is at the interface of the Buck Center for Reproductive Longevity and Equality (CRLE), the Global Consortium for Reproductive Longevity and Equality (GCRLE) and Buck Institute scientists.
Conduct experiments with both murine and human reproductive tissue. Experiments may include tissue harvest, dissection, and fixation; gamete and somatic tissue culture, maturation, manipulation, and injection; ovarian and folliculogenesis analysis; embryo culture; histology; protein biochemistry and mass spectrometry (in collaboration with proteomics core); immunohistochemistry; in situ hybridization; imaging; gene expression analysis; murine breeding and husbandry
Prepare samples, execute, and analyze data, and interpret integrative projects in reproductive biology and aging
Prepare research reports and manuscripts
Develop and implement appropriate administrative policies and procedures for the laboratory (animal protocols, biohazard protocols, etc.)
Maintain laboratory compliance and regulatory documents
Operate and maintain ReproHub laboratory equipment
Manage human biobanked tissue
Oversee/perform laboratory research/instruction, inventory planning and purchasing
Supervise ReproHub employees and trainees and oversee quality and accuracy of their work
Liaise among the ReproHub, internal Buck Institute departments and labs, and external institutes
Train investigators on particular techniques and/or instruments in the Hub
Manage invoicing and recharge for Hub users
PhD in Biomedical Science or related field with additional relevant experience in reproductive biology
4+ years of laboratory experience in a Reproductive Biology lab environment
In depth knowledge of mammalian reproductive biology
Experience in basic reproductive biology research techniques or assisted reproductive technology (ART)
Experience with mammalian models
Experience in reproductive techniques such as breeding, reproductive tissue dissection, gamete isolation, immunohistochemistry, immunofluorescence antibody staining, cell culture, and microscopy
Mouse colony management
Strong organizational skills and the ability to multitask
Attention to detail and execution of work protocols in a reproducible fashion
Excellent analytical and critical thinking skills
Proficiency with computers required, i.e. Microsoft Office and scientific software for processing of mass spectrometry experiments
Our success will ultimately change healthcare. At the Buck, we aim to end the threat of age-related diseases for this and future generations by bringing together the most capable and passionate scientists from a broad range of disciplines to identify and impede the ways in which we age. We are an independent, nonprofit institution located in Marin County, CA, with the goal of increasing human healthspan, or the healthy years of life. Globally recognized as the pioneer and leader in efforts to target aging—the number one risk factor for diseases including Alzheimer’s, Parkinson’s, cancer, macular degeneration, heart disease, and diabetes—the Buck seeks to help people live better longer. We are an equal opportunity employer and strive to create an atmosphere where diversity of identity, experience, and background are welcomed, valued, and supported. Candidates who contribute to this diversity are strongly encouraged to apply.