RESEARCH FELLOW - Nrf2 Function in Cystic Fibrosis/Gene Therapy
Cincinnati Children's Hospital Medical Center
Location: Cincinnati, Ohio
Academic / Research
Internal Number: 112135
A postdoctoral research fellow position is available in Dr. Assem Ziady's laboratory to study Cystic Fibrosis (CF). Focus areas are 1) understanding the regulation of Nrf2 activity and identify various interventions as therapy for Nrf2 dysfunction; and 2) examine and further develop non-viral DNA delivery vectors for CF gene therapy. These studies will use CF primary epithelial cells, CF animal models, and tissues from CF patients.
About Cincinnati Children's
Cincinnati Children's Hospital Medical Center is a premier pediatric research institution with over 900 diverse and productive faculty members. Here, researchers work collaboratively across specialties and divisions to address some of the biggest challenges we face today in improving child health. A strong network of research support services and facilities, along with institutional commitment to research, push our team of faculty, postdocs and support staff to explore the boundaries of what is possible, leading to significant breakthroughs. We are driven by our mission to improve child health and transform the delivery of care through fully integrated, globally recognized research, education and innovation.
1. Design, execute, and record laboratory experiments; apply standard scientific protocols to experiments, research, and improve current methods and evaluate innovative techniques. 2. Draft, write, and edit scientific reports, papers, journal articles, and abstracts. 3. Design and perform experiments and record data according to research protocol. Independently reproduce, evaluate, research, and improve techniques currently used. Adapt new methods to existing procedures and modify current experiments through scientific knowledge and intuition. Maintain accurate and detailed records of all laboratory work and experiments. 4. Develop, set-up, and verify new procedures in the laboratory. Standardize and establish new published procedures; evaluate innovative techniques. Develop new assays and new protocols; design formats. 5. Discuss relevant insights about experimental results with Faculty and provide useful recommendations and analysis. 6. Maintain an integral role in the laboratory's meetings, presentations, and publications. Present information on research and laboratory work to others at laboratory meetings, journal clubs, and seminars. 7. Troubleshoot and correct erroneous results or problems with laboratory equipment. Maintain and repair equipment; monitor proper use by personnel. 8. Maintain optimal protocol and assay accuracy by conducting regular quality and reproducibility checks. 9. Assist in preparing, writing, and maintaining fiscal budget. Monitor expenditures and prepare capital expenditure requests; track funding, maintain accurate balance, and resolve any discrepancies. 10. Follow policies and procedures governing the handling of confidential information as defined by Cincinnati Children's mission and applicable laws and regulations. Ensure timeliness, accuracy, availability, and security of information. 11. Perform routine procedures, including the collection and analysis of research data, which may affect decisions regarding future patient care. 12. Provide services in a manner to be regularly and conveniently available to meet the needs of Cincinnati Children's research initiatives as determined by department management and Cincinnati Children's governing body. 13. Maintain currency in field through continuing education, literature and seminars. Implement this knowledge into the Department. 14. Recommend approaches for improvement activities, recommend and perform new processes, collect and measure data, develop processes based on performance, and communicate results. 15. Ensure that work areas are organized and present a safe, accessible, effective and efficient environment. Manage attendance at required Cincinnati Children's training sessions, including radiation safety, laboratory safety, bloodborne pathogens, and OSHA. Comply with Infection Control policies and procedures. 16. Participate in establishing job requirements and goals; perform duties at the desired level of competency. 17. Understand, adhere to, and model Core Standards as defined organizationally and specifically within the department/unit. 18. Perform other duties as assigned.
EDUCATION/ WORK EXPERIENCE: Ph.D. in related discipline, MD, or equivalent required. The ideal candidates for the position will be recent PhDs with a strong background in one or more of the following: protein-protein interaction studies, redox biology, biochemistry, transcription factor activity, protein biomarker identification, animal models of disease. Experience with proteomics and mass spectrometry would be ideal. Evidence of strength in experiment design, data analysis, and a strong publication record are strongly desired. Background knowledge in other areas where this inflammatory pathway is relevant (cardiac, pulmonary, and neurological disease) would be beneficial.
REQUIRED SKILLS: Excellent written, verbal, and interpersonal communication skills. Demonstrate attention to detail, strong organizational skills, supervisory ability, and an innovative approach to experimental design. Computer literate and working knowledge of software applications (word processing, spreadsheet, and database). Analytical ability sufficient to compare data; mathematical ability sufficient to perform algebraic calculations and statistical analysis. Ability to synthesize information and to create and deal with new situations by applying past experiences. Expressed willingness to teach others and share results. Capable of meeting time demands necessary to execute experiments.
At Cincinnati Children’s, we come to work with one goal: to make children’s health better. We believe in a team approach, both in caring for patients and their families, and in advancing science and discovery. We strive to do better, and find energy and inspiration in our shared purpose. If you want to be the best you can be, you can do it at Cincinnati Children’s.