Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.
The Department of Informatics & Analytics (I&A) at Dana-Farber Cancer Institute (DFCI), led by the Chief Data and Analytics Officer (CDAO), is an operational department responsible for building an informatics and analytics ecosystem to support and grow DFCI research, clinical, and business operations missions. I&A provides the centralized acquisition, harmonization, management, and delivery of clinical molecular data within the Dana-Farber Cancer Institute (DFCI) and its collaborators across Brigham and Women???s Hospital, Boston Children???s Hospital, and external multi-institution collaborations such as AACR GENIE. This position provides technical leadership for the development of molecular data resources within DFCI, including our molecular data warehouse; our unified variant knowledgebase; and interfaces that expose clinical molecular data to consumers throughout the Institute. The current primary data type is somatic variants from various tumor sequencing assays, but additional initiatives involve germline variants and transcriptome data.??
We seek a hands-on technical leader who can distill priorities from a large network of stakeholders including oncologists, molecular pathologists, scientific leadership, vendors, and informatics staff who support and consume different stages of molecular data pipelines, while also articulating and addressing the bigger picture to integrate molecular data resources into a unified platform and maximize its value to stakeholders. The Technical Lead ??? Molecular Data will report to the Associate Director of Bioinformatics within I&A and will work in highly matrixed fashion with data consumers, program and project managers, software development managers and others.??
PRIMARY DUTIES AND RESPONSIBILITIES
Develop and maintain a roadmap of molecular data needs across all clinical genomic testing within DFCI. Work with program managers to solicit requirements from stakeholders across the Institute and help keep stakeholders informed of the roadmap and ongoing development.??
Lead development of DFCI???s central molecular data resource, including harmonization of molecular data across multiple tests and versions, genomic annotation, development of APIs that enable access to harmonized data, and assisting downstream consumers of molecular data with integration of data for various purposes.??
Identify a solution that meets DFCI???s molecular knowledgebase needs, with a focus on molecular pathology, and acknowledgement of the desire for a similar solution across medical oncology.??
Provide architectural and technical leadership on DFCI???s Bioinformatics Workbench project, which enables DFCI researchers and staff with a variety of bioinformatics knowledge to manage, process, and analyze sequencing data. This includes integration between on premises DFCI research data storage systems and a cloud-based analysis environment.??
Keep abreast of emerging cancer genomics data standards and integrate them into the roadmap as appropriate.??
Document requirements and relay to technical team via product roadmap, product backlog, user stories, and issue tracking tool.??
Lead technical team in development, maintenance, and monitoring of quality control processes and reliability efforts for automated molecular data pipelines. Build automated tests where possible that validate for non-sensical data scenarios based on scientific expertise.??
Work with development teams in agile process, driving sprints by ensuring team is building the right thing at the right time. Design and run smoke tests for non-automatable functions that verify functionality, especially to confirm that a release works.??
Contribute to end user documentation of molecular data, including data dictionaries.??
Participate in bioinformatics and scientific meetings that revolve around our source data when needed and devise a mechanism for involving the appropriate stakeholders as issues and questions around molecular data arise. Use lessons learned to further improve documentation of the nuances and complexities in molecular data.??
Serve as a resource for molecular data to product managers in related spaces such as research data delivery and clinical decision support as appropriate.??
Explore and assess genomic data and other advances in the public domain, guiding the bioinformatics product development team in adding additional annotations that may aid in the interpretation and contextualization of variants of interest in cancer.??
MINIMUM JOB QUALIFICATIONS
Advanced degree required. MS in computer science, software engineering or related field with minimum 7 years of experience in a biomedical, academic or health-care related environment; or, PhD in Bioinformatics, Genomics, Cancer Biology, or related field with 5+ years of experience in cancer research or clinical genetics environment
7+ years working as a lead software engineer, or software or data architect
5+ years??? experience working directly with molecular data; especially genomic variant data
5+ years??? experience analyzing/working with data (SQL, Python, Perl, etc.); demonstrated SQL skills and understanding of database design
Knowledge of cancer genomics data sets a plus (e.g., COSMIC, GENIE, GDC, TCGA, OncoKB, MetaKB, CIViC, MyCancerGenome)
KNOWLEDGE, SKILLS, AND ABILITIES REQUIRED??
Strong communication and organization required, with the ability to distill complex scientific topics into an easily digestible format??
Technical skills to enable data exploration and guidance of development team in nuances of molecular data??
Demonstrated ability to provide excellent customer support??
Working knowledge of molecular pathology workflows (case signout)??
Proven ability to effectively translate business requirements to functional requirements??
Requires minimal direction from leadership and possesses the ability to learn quickly??
Ability to cooperatively and effectively work within a team??
At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong.?? As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff.?? Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.
Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to under-served members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.