Career Center

Department: MED-Biochem&Molecular Genetics
Salary/Grade: RES/

Job Summary      

The Gao lab is seeking two postdoctoral scholars.

About us:

Dr. Ruli Gao's laboratory at Feinberg School of Medicine at Northwestern pioneers the development of  single-cell long reads sequencing technologies and computational methodologies as well as their applications in dissecting human diseases.  Dr. Gao has made significant contributions in understanding tumor evolution models by developing and applying single-cell sequencing technologies and bioinformatic algorithms.  These include development of the paradigm shift punctuated copy number evolution (PCNE) model that challenged Darwinian gradualism in tumor evolution (Nature Genetics, 2016), the bi-mode chemo-resistance evolution model where adaptive selection of genotypes and acquired reprogramming of phenotypes are activated in parallel (Cell, 2018), the high throughput nanogrid single nuclear RNA sequencing technology that opened the avenue of analyzing single-cell transcriptomes from archival frozen tissue samples (Nature Communications, 2017), the CopyKat, an integrative Bayesian algorithm to infer single-cell genetic architecture from scRNA-seq data (Nature Biotechnology, 2021), the scNanoGPS, a robust toolkit for analyzing single cell nanopore sequencing data (Shiau et al., 2022), the anaplastic transformation model of thyroid cancer (Lu et al., 2022) and mosaic mutation atlas of human hearts.

Position Descriptions:
Position #1: Postdoctoral Fellow in Bioinformatics

• Strongly interested in developing bioinformatic tools for analyzing single-cell third-generation sequencing data to dissect human diseases including cancer evolution, can therapeutic responses, heart diseases and transplantation rejection. 
• Recent graduate with PhD or MD/PhD in Bioinformatics, Genomics, Computational Biology, or equivalent areas.  

Position #2: Postdoctoral Fellow in Genomics

• Strongly interested in studying human disease genomics by developing and applying single-cell third-generation sequencing technologies to obtain same cell mega-omics including but not limited to single cell isoforms, mutations, structure variations, copy numbers and methylations. 
• Recent graduate with PhD or MD/PhD in Molecular Genetics, Genomics, Molecular Biology, Biochemistry, Cell Biology, or equivalent areas.  

Please visit https://labs.feinberg.northwestern.edu/gao/ to learn more. To apply, please email your CV and cover letter directlty to Dr. Gao at ruli.gao@northwestern.edu   Please do do not apply through this website.

Specific Responsibilities

• Studying metabolism, epigenetics and circadian rhythms

Minimum Qualifications:

• Ph.D.

Minimum Competencies:

• Written and verbal communications skills, organizational skills, ability to work as a team.

Preferred Qualifications:

• PhD

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