Columbia University is a leader in biomedical research and is a National Cancer Institute-designated Comprehensive Cancer Center. Columbia's Vagelos School of Physicians and Surgeons is amongst the top research universities and provides an outstanding intellectual environment. The Herbert Irving Comprehensive Cancer Center (HICCC) at Columbia University Irving Medical Center provides outstanding Biomedical Research Cores. The HICCC houses 12 core facilities or shared resources that provide services essential to basic and translational cancer research, to which the applicant will have continued full access on a 24/7 basis.
We are seeking a highly motivated Postdoctoral Research Scientist for Dr. Xiao Zhao's laboratory at the Herbert Irving Comprehensive Cancer Center. Our laboratory specializes in liver biology, with a particular focus on using complementary model systems to study molecular mechanisms underlying cholestatic liver diseases, including zebrafish, mouse, and in vitro cell culture systems. The research focus will be on elucidating the mechanisms driving cellular heterogeneity within cholangiocytes and how cell-type-specific characteristics determine cellular behavior and disease phenotype. Studies will include cell isolation, traditional molecular techniques, and assays, gene editing using CRISPR -CAS9, RNA -Seq, Epigenetic profiling, bioinformatics using both in vitro systems and whole animal models.
Columbia University is one of the world's most important centers of research and at the same time a distinctive and distinguished learning environment for undergraduates and graduate students in many scholarly and professional fields. The University recognizes the importance of its location in New York City and seeks to link its research and teaching to the vast resources of a great metropolis. It seeks to attract a diverse and international faculty and student body, to support research and teaching on global issues, and to create academic relationships with many countries and regions. It expects all areas of the university to advance knowledge and learning at the highest level and to convey the products of its efforts to the world.