Postdoctoral Scholar Position in Digestive Diseases Koon Lab 2022-2023
University of California Los Angeles
Location: Los Angeles, California
Internal Number: 3289227
Postdoctoral Scholar Position in Digestive Diseases Koon Lab 2022-2023 University of California Los Angeles
Requisition Number: JPF07708
The laboratory of Professor Michael Koon in the UCLA Department of Medicine, Division of Digestive Diseases is seeking a full-time postdoctoral fellow. The focuses of the Koon Lab are on Crohn's disease-associated intestinal fibrosis, C. difficile infection, obesity, and diabetes.
The Koon Lab is developing orally active formulations to treat gastrointestinal and metabolic diseases. These formulations include metabolites, small molecules, and microbiota. Dr. Koon has five active grants, including a new NIH R01 grant and collaboration with industry. The lab has current projects to discover efficacies and mechanisms of action of therapeutic agents as well as exploring new therapeutic approaches and biomarkers for various diseases. The Koon Lab works with mouse models, human blood and tissue, and cell and enteroid cultures. Please see the Koon Lab webpage to understand more: https://www.uclahealth.org/gastro/research/koon-lab
Specific techniques used in the lab include:
Molecular biology: gene knockdown and overexpression, qPCR, western blot, ELISA
Immunocytochemistry, immunohistochemistry, fluorescence, and brightfield microscopy
Use of automated microscopy for high-content screening.
Measurement of intestinal permeability and identifying tight junctions.
Assessment of immune phenotype
Bioinformatic analysis of high-throughput transcriptomic data, proteomics, and microbiome data
Building machine learning algorithms for performing complex analyses
Mouse models: dissection of the gut, testing of blood cells, cytokines, and biochemistry, measurement of gene and protein expression, preparation of gut tissue for immunohistochemistry, preparation of gut organoids
Responsibilities will include
Running projects independently
Supervision of undergraduate and medical students
Interact with various units and staff to handle tasks
Maintaining and organizing lab inventory
Management of mouse and hamster colonies and study cohort
Management of biohazardous and chemical hazard materials.
Maintenance of cell cultures
Writing of research papers and grant applications
The ideal candidate will have multidisciplinary expertise and creativity to initiate new projects from concept to publication. The candidate will also quickly learn new skills and knowledge to adapt to changing environments. First year Ph.D. graduates are preferred. Please see the Koon Lab webpage to understand more: https://www.uclahealth.org/gastro/research/koon-lab
The start date is flexible, but the postdoctoral fellow should join within the 2022 calendar year.
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The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy, see: UC Nondiscrimination & Affirmative Action Policy, https://policy.ucop.edu/doc/4000376/DiscHarassAffirmAction jeid-ff23004962628e4e98473b656fc82f3e
UCLA is known worldwide for the breadth and quality of its academic, research, health care, cultural, continuing education and athletic programs. UCLA offers undergraduate degrees in more than 127 majors and graduate degrees in 198 program areas. UCLA has 11 highly regarded professional schools. Eight are ranked among the nation's top 15 in their field by U.S. News & World Report. UCLA is consistently among the most popular campus in the nation for undergraduate applicants. The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to age, race, color, religion, sex, national origin, disability, or protected veteran status. Benefits:UCLA offers a comprehensive benefits package, including an average of three weeks' vacation per year; an average of 12 days per year sick leave; 13 paid holidays per year; health, dental and optical benefits; life insurance; disability insurance; the University of California Retirement Plan with 5 year vesting and various voluntary UC Savings Plans. There are also special programs and privileges available, such as accessibility to cultural and recreational programs, athletic events, and the University Credit Union.