The Biomarkers Core Laboratory at the Irving Institute for Clinical and Translational Research is seeking a Staff Associate III with expertise in the field of untargeted metabolomics, mass spectrometry and related data processing and bioinformatics. This position will involve GC-HRMS and LC-HRMS profiling of endogenous and exogenous metabolites in support of precision medicine metabolomics and exposomics initiatives in partnership between Irving Institute for Clinical and Translational Research, the Vagelos College of Physicians and Surgeons and the Mailman School of Public Health under the scientific guidance of Prof. Gary Miller. The ideal candidate will have a strong background in biological mass spectrometry with technical expertise in untargeted analysis and processing workflows for high-resolution mass spectrometry data sets.
Establish and develop GC and LC-MS workflows for untargeted metabolomics
Develop and customize sample preparation protocols for complex biological matrices
Preparation and analysis of samples with both GC-HRMS and LC-HRMS Thermo Orbitrap analyzers.
Develop and implement bioinformatic workflows for data extraction, feature identification and OMICS data analysis.
Operate and maintain mass spectrometry instruments including the GC/LC Thermo Orbitrap MS platforms.
Prepare data reports and standard operating procedure documentation.
Interact with investigator clients to support sample management, study design and data interpretation.
Bachelor's degree in related research field and 4-6 years' experience in high-resolution mass spectrometry and bioinformatics is required.
Master's degree or higher is preferred
Hands-on expertise in operating, maintaining and troubleshooting Thermo Orbitrap Exploris GC240 and Q-Exactive HFX, E240 LC/MS
Experience in conducting large-scale unbiased metabolomics studies (design, sample preparation, QC monitoring, data analysis and reporting)
Expertise in various metabolite extraction techniques from biological tissues and other matrices
Demonstrated experience in applying bioinformatic and statistical software tools and suites to large untargeted metabolomics datasets
Experience in setting up well validated, targeted MRM based LCMS assays for small molecule analysis is desired
Excellent communication and interpersonal skills
Ability to maintain effective working relationships with supervisors, researchers, staff and other personnel
Columbia University is an Equal Opportunity Employer / Disability / Veteran
Columbia University is one of the world's most important centers of research and at the same time a distinctive and distinguished learning environment for undergraduates and graduate students in many scholarly and professional fields. The University recognizes the importance of its location in New York City and seeks to link its research and teaching to the vast resources of a great metropolis. It seeks to attract a diverse and international faculty and student body, to support research and teaching on global issues, and to create academic relationships with many countries and regions. It expects all areas of the university to advance knowledge and learning at the highest level and to convey the products of its efforts to the world.