The Rauchman (wet lab) and Dietmann labs (bioinformatics) are looking for a post-doctoral fellow to work on a collaborative project investigating epigenetic mechanisms in kidney development and disease. The project will explore how chromatin remodeling complexes (NuRD and SWI/SNF) and tissue restricted transcription factors cooperatively regulate cell fate decisions during formation of the nephron and in regenerating epithelia after injury. The main focus of our work is in understanding 1) the mechanistic basis of congenital anomalies of the kidney and 2) defining the epigenetic changes that determine healthy vs. diseased cell states in the adult kidney. To address these questions, we use a multi-omics approach that integrates single cell technologies, chromatin profiling and conformation capture methods (CUT&RUN, Hi-ChIP), spatial transcriptomics and Cas9-mediated epigenetic editing. Studies are conducted primarily in mouse models and primary cells; key findings will be validated in human samples. The opportunity will provide training and mentoring in genomic techniques (Rauchman lab) and computational biology (Dietmann lab) in a collaborative and collegial environment.
Ph.D., M.D. or equivalent terminal or doctoral degree.
Experience in bioinformatics.
Interest in further developing computational skills in parallel with learning wet lab genomic techniques.
Ability to guide research projects and maintain detailed records of experimental work.
Background in or strong desire to learn developmental biology and epigenomics.
Ability to work collaboratively with other members of the research group.
Excellent oral and written communication skills.
This position works in a laboratory environment with potential exposure to biological and chemical hazards.Â The individual must be physically able to wear protective equipment and to provide standard care to research animals.
Ph.D., M.D. or equivalent terminal or doctoral degree.
$54,840.00 - $54,840.00 / AnnuallyThe salary range reflects base salaries paid for positions in a given job grade across the University. Individual rates within the range will be determined by factors including one's qualifications and performance, equity with others in the department, market rates for positions within the same grade and department budget.
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