Human genetics has long been appreciated as source of understanding the molecular factors that underlie differences observed between individuals. In particular, patient-derived cell lines, such as induced pluripotent stem cells (iPSCs), represent a unique opportunity to leverage inter-individual human variation for the discovery of novel genetic and molecular contributors to disease risk. Cardiometabolic diseases such as atherosclerotic cardiovascular disease (ASCVD) and nonalcoholic fatty liver disease (NAFLD) are well known to be heritable within families, but the genetic determinants that contribute to individual level risk for these diseases is not entirely known. As iPSCs retain the genetic
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