The Malone laboratory is a Human Kidney Transplant Immunology and Nephrology research Group headed by Dr. Andrew Malone and is located at Washington University in St. Louis, within the Department of Medicine, Division of Nephrology. Our focus is to gain an understanding of the immune cells driving the alloimmune response in the rejecting kidney transplant and how these cells interact with other immune and kidney cells. Our overarching goal is to gain scientific knowledge of the immune cell microenvironment in the rejecting kidney transplant and other kidney transplant diseases. We use cutting edge computational and wet lab experimental approaches such as single cell multiomics, high throughput sequencing methods, and multiparameter flow cytometry to determine immune responses. In parallel with our human studies we use a mouse model of kidney transplant rejection to further understand immune responses and efficacy of potential therapies. We welcome a diverse group of individuals/candidates who are experienced, highly motivated and autonomous post-doctoral research scientists.
We do all our own computational and bioinformatics analyses in house.Â Our research focus can be subdivided into four broad areas:
Single cell multiomics experiments using human kidney transplant biopsy tissues with rejection, normal tissue, and other pathologies.
T and B cell repertoire analysis in tissue and blood from kidney transplant patients.
Highly multiplexed imaging analysis on human kidney transplant biopsies.
Develop and carry out their own research projects aiming at deciphering mechanisms of immune responses in the human kidney transplant under the guidance of Dr. Malone.
Develop their computational and coding skills in parallel with wet lab experiments.
Develop new approaches and tools, participate and add their expertise to other ongoing projects in the group.
Explore their own ideas, write grants, and present their work at conferences.
Ph.D., M.D. or equivalent terminal or doctoral degree in immunology, genetics, and/or molecular/cell biology.
Interest in wet lab and translational research.
Ability to work independently and interactively in a team setting; responsible and organized; and have enthusiasm for research.
Experience in immunobiology and pathogenesis of immunological disorders.
Experience in bioinformatics.
This position works in a laboratory environment with potential exposure to biological and chemical hazards. The individual must be physically able to wear protective equipment and to provide standard care to research animals.
Base pay is commensurate with experience.
Applicant Special Instructions
Please contact Dr. Malone (email@example.com) directly with CV and cover letter with research interests.
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.
Washington University in St. Louis is committed to providing a comprehensive and competitive benefits package to our employees. Benefits eligibility is subject to employment status, full-time equivalent (FTE) workload, and weekly standard hours. Please visit our website at https://hr.wustl.edu/benefits/ to view a summary of benefits.
Washington University is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration without regard to an individualâ™s sex, race, color, religion, age, disability status, protected veteran status, national or ethnic origin, gender identity or expression, sexual orientation. Women, minorities, protected veterans and the disabled are strongly encouraged to apply.
Washington University is dedicated to building a diverse community of individuals who are committed to contributing to an inclusive environment â“ fostering respect for all and welcoming individuals from diverse backgrounds, experiences and perspectives. Individuals with a commitment to these values are encouraged to apply.
Washington University in St. Louis, a medium-sized, independent university, is dedicated to challenging its faculty and students alike to seek new knowledge and greater understanding of an ever-changing, multicultural world. The University offers more than 90 programs and almost 1,500 courses leading to bachelor's, master's and doctoral degrees in a broad spectrum of traditional and interdisciplinary fields, with additional opportunities for minor concentrations and individualized programs. The faculty is composed of scholars, scientists, artists and members of the learned professions. They serve society by teaching; by adding to the store of human art, creativity, understanding, and wisdom; and by providing direct services, such as health care.