The Prince laboratory studies how the immune system regulates fetal and neonatal development and disease. In the lung, early activation of the immune system causes lasting changes that impact how the lung repairs following injury. Many questions remain regarding immune development, function, and contribution to disease processes, particularly in preterm infants and children. Using both animal models and patient-based studies, our work investigates differences in lung macrophage populations and how immaturity of macrophage development contributes to bronchopulmonary dysplasia and neonatal pneumonia.
The Prince Lab is seeking a Life Science Research Professional 3 with experience in mouse models of infectious disease . This Research Professional will perform complex functions and activities involved in defined research projects, and independently conduct a major portion of the research project(s). The main focus of the research activities will use animal models of disease to understand the molecular biology of newborn lung infection and inflammation. The Research Professional will use state of the art approaches to analyze transcriptomic and epigenetic regulation of specific lung cell populations following injury or during lung repair. In addition, this Research Professional will play key roles in overseeing laboratory operations and orienting new lab personnel, students, and trainees.
Design research approaches for a major portion of research project(s), including background research, experimental design and execution, problem-solving, and writing up for publication.
Develop new protocols; test and evaluate a variety of approaches.
Perform complex (lab and/or field) experiments, and maintain detailed records of experiments and outcomes; analyze and interpret research data resulting from original procedures and methods.
Assist with new research proposals and applications for funding and grants.
Lead or participate in multidisciplinary teams across different faculties or schools.
Prepare periodic progress reports or written reports on all phases of the research project.
Contribute substantively to the preparation of papers for publication, especially in the results section. May be a co-author on publications. Present ongoing work and findings to colleagues at academic conferences.
Perform ongoing literature review to remain current with new procedures and related research; propose new research directions based on new advances discussed in literature.
Oversee supply and equipment budget under minimal supervision of principal investigator or business manager.
Work with health and safety department to ensure lab complies with regulations and all required trainings.
Formally supervise and train new staff or students as needed, including hiring, performance management, and related duties, in addition to instruction on techniques and consultation on project work.
* - Other duties may also be assigned
Experience in mouse models of infectious disease or PhD in a field that used murine disease models for the majority of the thesis project
Experience with FACS-based cell sorting.
Expertise in transcriptional profiling, including RNAseq and single cell RNAseq.
EDUCATION & EXPERIENCE (REQUIRED):
Bachelor's degree in related scientific field and four years of relevant work experience; or Master's degree in a related scientific field and two years relevant experience; or PhD in related science field.
KNOWLEDGE, SKILLS AND ABILITIES (REQUIRED):
Comprehensive understanding of scientific principles.
Expert level knowledge and skills in field of science related to research project.
General computer skills, experience with databases and scientific applications, and ability to quickly learn and master computer programs.
Strong analytical skills and excellent judgment.
Ability to work under deadlines with general guidance is essential.
Excellent organizational skills and demonstrated ability to complete detailed work accurately.
Developing project management skills.
CERTIFICATIONS & LICENSES:
Frequently stand, walk, twist, bend, stoop, squat, grasp lightly, use fine manipulation, grasp forcefully, perform desk-based computer tasks, use telephone, write by hand, lift, carry, push and pull objects weighing over 40 pounds.
Occasionally sit, kneel, crawl, reach and work above shoulders, sort and file paperwork or parts.
Rarely climb, scrub, sweep, mop, chop and mix or operate hand and foot controls.
Must have correctible vision to perform duties of the job.
Ability to bend, squat, kneel, stand, reach above shoulder level, and move on hard surfaces for up to eight hours.
Ability to lift heavy objects weighing up to 50 pounds.
Ability to work in a dusty, dirty, and odorous environment.
Position may require repetitive motion.
* - Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of his or her job.
May require working in close proximity to blood borne pathogens.
May require work in an environment where animals are used for teaching and research.
Position may at times require the employee to work with or be in areas where hazardous materials and/or infectious diseases are present.
Employee must perform tasks that require the use of personal protective equipment, such as safety glasses and shoes, protective clothing and gloves, and possibly a respirator.
May require extended or unusual work hours based on research requirements and business needs.
Stanford is an equal opportunity employer and all qualified applicants will receive consideration without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status, or any other characteristic protected by law.
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Located between San Francisco and San Jose in the heart of Silicon Valley, Stanford University is recognized as one of the world's leading research and teaching institutions. Leland and Jane Stanford founded the University to "promote the public welfare by exercising an influence on behalf of humanity and civilization." Stanford opened its doors in 1891, and more than a century later, it remains dedicated to finding solutions to the great challenges of the day and to preparing students for leadership in a complex world. The University's thriving diverse community is comprised of nearly 7000 undergraduate students, 12000 graduate students, 2000 faculty members, 1900 postdoctoral scholars, and over 11,000 academic and administrative staff in seven schools including several interdisciplinary research centers and institutes. The campus spreads over 8000 contiguous acres and nearly all undergraduates live on campus. Stanford offers bachelor's and master's degrees in addition to doctoral degrees (PhD, MD, DMA and JD) plus a number of professional and continuing education programs and certifications. More at http://facts.stanford.edu and http://www.stanford.edu. Stanford is an equal empl...oyment opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. Stanford also welcomes applications from others who would bring additional dimensions to the University’s research, teaching and clinical missions.