The Department of Genetics at Stanford University is seeking a Senior Research Scientist (Life Science Research Professional 3) focusing on genome editing, molecular biology, biochemistry, and/or genomics technology development to join the Engreitz Laboratory to map the regulatory wiring of the human genome to discover genetic mechanisms of heart diseases. The Engreitz Lab will launch at the Stanford University Department of Genetics and Children's Heart Center starting in 2020. The ideal candidate will join as soon as possible. Candidate will have the option to train with the Engreitz group at the Broad Institute in Cambridge, MA during a transition period in 2020. Lab overview: DNA regulatory elements in the human genome, which harbor thousands of genetic risk variants for common and rare diseases and could reveal targets for therapeutics that aim to precisely tune cellular functions - if only we could map the complex regulatory wiring that connects 2 million regulatory elements with 21,000 genes in thousands of cell types in the human body. We have recently developed new approaches that could enable mapping this regulatory wiring at massive scale (see Fulco et al. Science 2016, Fulco et al. bioRxiv 2019). We invent new tools combining experimental and computational genomics, biochemistry, molecular biology, and human genetics to assemble regulatory maps of the human genome and uncover biological mechanisms of heart disease. We are looking for creative and passionate people at any stage in their careers. The research scientist will work closely with the PI to invent new molecular and genomic technologies, apply these technologies at large scale to understand the regulatory wiring of the genome, and mentor and train other members in the Engreitz Labory. Specific projects include: to develop CRISPR-based tools to map the functions of thousands of noncoding variants and enhancers; chart enhancer-promoter regulation in every cell type and state in the developing heart using single-cell CRISPR and epigenomic tools; understand enhancer-promoter biochemical specificity by synthetic DNA engineering of millions of enhancer-promoter combinations; and develop novel computational models to understand genetic regulation of heart disease by noncoding variants. For more information and recent work, see www.engreitzlab.org. The Engreitz Laboratory is a dynamic, interdisciplinary workplace that will provide unique access to cutting edge technologies and scientific thought, with the potential for widespread recognition of scientific contributions. We value a diversity of values, backgrounds, and approaches to solving problems.
The candidate for this position should have hands-on experience in molecular biology, genomics, and cellular assay development; experience with quantitative data analysis; curiosity in research and creativity in problem-solving; strong interpersonal and collaboration skills; experience building or managing teams; outstanding verbal and written communication abilities; ability to adapt to and effectively manage changes in a fast paced and dynamic environment; and have a passion for science and sense of urgency to find new medicines to benefit patients.
Make fundamental discoveries about gene regulation and the genetics of cardiovascular disease
Together with PI and other lab members, design and execute scientific projects
Develop and apply functional genomics techniques, including epigenomics, single-cell, imaging, and CRISPR-based assays in human cells and/or in vivo models of disease
Evaluate and recommend new emerging technologies, approaches, and problems
Train, mentor, and/or supervise lab members in experimental techniques, scientific design, and other skills
Design and lead independent projects
Collaborate with a team of experimentalists and computational biologists
Train and mentor other lab members
Create scientifically rigorous visualizations, communications, and presentations of results
Contribute to generation of protocols, publications, and intellectual property
Grade: H FTE: 100%
* - Other duties may also be assigned.
Ph.D. in Biology, Biochemistry, Biophysics, Genetics, Bioengineering, or related life science field is preferred. Highly motivated candidates of all levels are encouraged to apply.
Hands-on experience in technology development, molecular biology, genomics, and cellular assay development
Experience with quantitative data analysis
Experience with CRISPR targeting ES/iPS cells or single-cell RNA-seq a plus
Curiosity in research and creativity in problem-solving
A great team member with strong interpersonal and collaboration skills
Outstanding verbal and written communication abilities
Ability to adapt to and effectively manage changes in a fast paced and dynamic environment
A passion for science and sense of urgency to find new medicines to benefit patients
EDUCATION & EXPERIENCE (REQUIRED): Bachelor's degree in related scientific field and four years of relevant work experience; or Master's degree in a related scientific field and two years relevant experience; or PhD in related science field.
KNOWLEDGE, SKILLS AND ABILITIES (REQUIRED):
Comprehensive understanding of scientific principles.
Expert level knowledge and skills in field of science related to research project.
General computer skills and experience with databases and scientific applications
Strong analytical skills and excellent judgment.
Ability to work under deadlines with general guidance is essential.
Excellent organizational skills and demonstrated ability to complete detailed work accurately.
Developing project management skills.
CERTIFICATIONS & LICENSES: None
Frequently stand, walk, twist, bend, stoop, squat, grasp lightly, use fine manipulation, grasp forcefully, perform desk-based computer tasks, use telephone, write by hand, lift, carry, push and pull objects weighing over 40 pounds.
Occasionally sit, kneel, crawl, reach and work above shoulders, sort and file paperwork or parts.
Rarely climb, scrub, sweep, mop, chop and mix or operate hand and foot controls.
Must have correctible vision to perform duties of the job.
Ability to bend, squat, kneel, stand, reach above shoulder level, and move on hard surfaces for up to eight hours.
Ability to lift heavy objects weighing up to 50 pounds.
Position may require repetitive motion.
* - Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of his or her job.
May require working in close proximity to blood borne pathogens.
May require work in an environment where animals are used for teaching and research.
Position may at times require the employee to work with or be in areas where hazardous materials and/or infectious diseases are present.
Employee must perform tasks that require the use of personal protective equipment, such as safety glasses and shoes, protective clothing and gloves, and possibly a respirator.
May require extended or unusual work hours based on research requirements and business needs.
WORK STANDARDS (from JDL):
Interpersonal Skills: Demonstrates the ability to work well with Stanford colleagues and clients and with external organizations.
Promote Culture of Safety: Demonstrates commitment to personal responsibility and value for safety; communicates safety concerns; uses and promotes safe behaviors based on training and lessons learned.
Subject to and expected to comply with all applicable University policies and procedures, including but not limited to the personnel policies and other policies found in the University's Administrative Guide, http://adminguide.stanford.edu.
Stanford is an equal opportunity employer and all qualified applicants will receive consideration without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status, or any other characteristic protected by law.
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Located between San Francisco and San Jose in the heart of Silicon Valley, Stanford University is recognized as one of the world's leading research and teaching institutions. Leland and Jane Stanford founded the University to "promote the public welfare by exercising an influence on behalf of humanity and civilization." Stanford opened its doors in 1891, and more than a century later, it remains dedicated to finding solutions to the great challenges of the day and to preparing students for leadership in a complex world. The University's thriving diverse community is comprised of nearly 7000 undergraduate students, 12000 graduate students, 2000 faculty members, 1900 postdoctoral scholars, and over 11,000 academic and administrative staff in seven schools including several interdisciplinary research centers and institutes. The campus spreads over 8000 contiguous acres and nearly all undergraduates live on campus. Stanford offers bachelor's and master's degrees in addition to doctoral degrees (PhD, MD, DMA and JD) plus a number of professional and continuing education programs and certifications. More at http://facts.stanford.edu and http://www.stanford.edu. Stanford is an equal empl...oyment opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. Stanford also welcomes applications from others who would bring additional dimensions to the University’s research, teaching and clinical missions.