The UCSF Department of Neurological Surgery and the Director of the UCSF Brain Tumor Center is recruiting a highly motivated candidate with prior laboratory experience to fill a Staff Research Associate II position.
The Brain Tumor Center at UCSF focuses on developing new treatments for patients with malignancies of the central nervous system by
studying the mechanisms through which brain tumors develop and become resistant to treatments and
identifying novel therapeutic targets using molecular biology, CRISPR genome and epigenome editing, biochemistry, mouse genetics, bioinformatics, pharmacology, and multidisciplinary collaborations.
We work collaboratively with basic scientists, computational biologists, and physician-scientists at the UCSF Helen Diller Cancer Center and broadly throughout the UCSF Campuses. Please refer to https://braintumorcenter.ucsf.edu/research for an overview of research efforts.
The Staff Research Associate II will play an instrumental role in developing and deploying genetic and epigenetic editing technologies for treating malignant gliomas, working side-by-side with physician-scientist investigator Dr. John Liu (MD/PhD) and under supervision and direction of Dr. Mitchel Berger, Director of the UCSF Brain Tumor Center.
This project specifically involves close collaboration with the labs of David Raleigh, Luke Gilbert, and the UCSF Preclinical Therapeutics Core. The employee will learn and utilize a variety of research techniques and have the opportunity to be a co-author on publications.
Job responsibilities and opportunities include but are not limited to:
Molecular biology including molecular cloning, PCR, DNA/RNA/Protein analysis, DNA methylation epigenetic analysis including bisulfite sequencing
Culturing human and mouse cancer cell lines, primary brain tumor cultures, and organoids
Flow cytometry, immunofluorescence, and confocal microscopy analysis
Performing gene knockdown and epigenetic editing using engineered CRISPR/Cas9 technologies, including genome-wide CRISPR screens
Assisting with mouse colony management, including breeding, weaning, tagging, and PCR genotyping
Assisting with intracranial xenograft studies and pharmacologic experiments in mice
Dissection and dissociation of tumor xenografts for single cell RNA-seq and multi-omics analysis
Assisting with lab maintenance duties including acquisition of materials and documentation
Prior familiarity with these techniques is a plus but not required, and a willingness to learn new techniques is expected. In addition, the successful applicant will receive direct mentorship to ensure that specific laboratory responsibilities are tailored and directed toward future career objectives, such as the pursuit of a MD, biomedical PhD, or MD/PhD.
Please note: The compensation ranges listed online for roles not covered by a bargaining unit agreement are very wide, however a job offer will typically fall in the range of 80% - 120% of the established mid-point. An offer will take into consideration the experience of the final candidate AND the current salary level of individuals working at UCSF in a similar role.
For roles covered by a bargaining unit agreement, there will be specific rules about where a new hire would be placed on the range.
The University of California, San Francisco (UCSF) is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and high-quality patient care. It is the only UC campus in the 10-campus system dedicated exclusively to the health sciences.