Postdoctoral Research Scientist - Human Tissue Immunity
Location: New York, NY
Internal Number: 101858
The laboratory of Dr. Stuart Weisberg at Columbia University Irving Medical Center focusses on the study of tissue immunity, and the role of innate and adaptive immune cells in shaping protective and pathologic tissue immune responses within specialized tissue microenvironments. We are now looking for an energetic, meticulous and dedicated post-doctoral research scientist to participate in studies of human tissue immunity with a focus on the immune cells that reside in human pancreas and upper gastrointestinal tract. Our research draws on collaboration with a human organ donor resource at Columbia University Medical Center as well as studies of patient samples in collaboration with surgeons at the Columbia Pancreas Center. Our lab employs techniques for isolation of primary immune cells from human pancreas. For analysis of immune cell antigen specificity, differentiation states and functional profiles, the lab routinely performs primary immune cell culture, single cell RNA sequencing, and flow cytometry. We also use automated multispectral imaging platforms for analysis of tissue immune cell density, activation states and interaction with other immune and non-immune cells in situ. Our ongoing studies focus on defining how T cells interact with specialized antigen presenting cells resident within human tissues, and how metabolic stressors such as obesity reshape tissue immune cell landscapes and interactions in ways that predispose to organ dysfunction and disease.
Overall, the successful candidate will join a large multi-investigator research effort and the work will afford opportunities to acquire skills that integrate cellular immunology, computational biology and human anatomy.
Minimum Degree Required: Ph.D.
Preferred Qualifications: Experience with isolating human immune cells, performing flow cytometry for analysis and cell sorting, working with primary immune cells in tissue culture. Familiarity with multiparameter imaging and analysis platforms such as Vectra, Halo and Codex. Working knowledge of scripting languages R and Python for computational data analysis.
Please apply directly to Interfolio - CV required
Columbia University is an Equal Opportunity Employer / Disability / Veteran
Columbia University is one of the world's most important centers of research and at the same time a distinctive and distinguished learning environment for undergraduates and graduate students in many scholarly and professional fields. The University recognizes the importance of its location in New York City and seeks to link its research and teaching to the vast resources of a great metropolis. It seeks to attract a diverse and international faculty and student body, to support research and teaching on global issues, and to create academic relationships with many countries and regions. It expects all areas of the university to advance knowledge and learning at the highest level and to convey the products of its efforts to the world.