Path 1: Research Assistant, Cell and Molecular Biology
Research Project DescriptionOrganismal development depends on the linear genome sequence and its thousands of genes controlled by millions of regulatory sequences. The three-dimensional (3D) chromatin architecture that orchestrates the interplay between these regulatory elements and their target genes also plays an essential role in correct expression of developmental genes. However, compared to our knowledge of the regulatory sequences, the understanding of the 3D genome organization in human and other eukaryotes is still limited. Recent advances in technologies to map the 3D genome architecture have accelerated the pace of discovery. We also know that there are several classes of architectural proteins involved in the 3D organization of chromatin, including pro
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