Postdoctoral Research Scientist - Pathology and Cell Biology (Molecular Biology)
Location: New York, NY
Internal Number: 95544
The Siegelin lab within the Department of Pathology and Cell Biology is hiring a highly-skilled and professional postdoctoral research scientist to begin immediately. The lab is currently funded by three R01 type research grants and investigates novel treatments for malignant brain tumors by interrogating tumor cell metabolism, the epigenome and cell death mechanisms. Hereby, the focus rests on glioblastoma, the most common primary brain tumor in adults with a dismal prognosis. Recent publications by our group that are highly representative of our current work are:
3. Nat Commun. 2017 Oct 20;8(1):1067. doi: 10.1038/s41467-017-00984-9.
To study these aspects, cell culture (stem-like glioblastoma cells, patient-derived xenograft cultures) and orthotopic glioblastoma in vivo models are being used as the main models. Genetic approaches, including but not limited to lentiviral/adenoviral based gene silencing (shRNA)/knock-out (CRISPR/Cas9)/overexpression techniques are implicated in our studies. Standard biochemical techniques, i.e. western blotting and co-immunoprecipitations, are instrumental. Genetic and epigenetic techniques include ATAC-seq, CHIP-seq, RNA-seq or standard microarray analysis with basic bioinformatics skills. Metabolism is mainly investigated by extracellular flux analysis and stable isotope tracing studies.
The CUMC Dept of Pathology and Cell Biology a world-class group of investigators that is one of the top-ranked Pathology Departments in the country that provides a supportive and collegial environment with extensive opportunities for professional development and advancement to top tier careers in academia and industry. Its location on the Upper West Side of Manhattan enables access to the multiple sites of interest, culture, and lifestyle in New York City.
Ph.D. M.D. or MD/Ph.D. Prior experience with lentiviral CRISPR library screens as well as single-RNA-seq would be highly appreciated but is not required. Competitive candidates for this position should be self-motivated and highly dedicated to science. The candidate should display efficient organization and be able to prioritize assignments/tasks. Outstanding oral, written, and interpersonal communication skills are required as is the ability to work both independently as well as collaboratively in a multidisciplinary environment. It is expected that the candidate can assist in teaching graduate students during their rotations. We strongly encourage and favor grant applications for our trainees and are highly dedicated to their career advancement.
Ph.D. in Molecular Biology
Interested candidates should submit their CV and the contact information of three professional references to the attention of Dr. Markus Siegelin.
Columbia University is an Equal Opportunity Employer / Disability / Veteran
Columbia University is one of the world's most important centers of research and at the same time a distinctive and distinguished learning environment for undergraduates and graduate students in many scholarly and professional fields. The University recognizes the importance of its location in New York City and seeks to link its research and teaching to the vast resources of a great metropolis. It seeks to attract a diverse and international faculty and student body, to support research and teaching on global issues, and to create academic relationships with many countries and regions. It expects all areas of the university to advance knowledge and learning at the highest level and to convey the products of its efforts to the world.