The Aguirre laboratory at Dana-Farber Cancer Institute and Harvard Medical School studies the genetics and biology of gastrointestinal (GI) cancers, particularly pancreatic cancer. We utilize variety of molecular biology and genomic approaches to understand GI cancer with three major focus areas: 1) Discovery and validation of the new therapeutic targets in GI cancers; 2) Investigating RAS biology and targeting in pancreatic cancer; and 3) Understanding the genetic and phenotypic subtypes of pancreatic cancer using single cell genomic and transcriptomic analysis of tumor biopsies and patient-derived organoid models. Research in the laboratory ranges from basic mechanistic investigation of cancer gene function or novel small molecule therapeutics to highly translational genomic and functional studies of patient-derived tissues from clinical trials. The Aguirre lab works collaboratively within the Dana-Farber Hale Center for Pancreatic Research (https://halecenter.dfci.harvard.edu/), the Lustgarten Foundation Dedicated Research Lab (https://lustgarten.org/research/our-lab/) and the Broad Institute of Harvard and MIT. Team members include laboratory investigators, clinical investigators and computational biologists at both Dana-Farber Cancer Institute and the Broad Institute.

• PhD, MD or MD/PhD in biological sciences or equivalent
• Strong leadership skills and experience working in teams.
• Strong work ethic, positive attitude, team-centered mentality and most importantly a passion for developing new therapeutic approaches for cancer.
• Outstanding interpersonal skills and excellent verbal and written communication skills.
• Background in molecular and/or cell biology, biochemistry, genomics, cancer biology or computational biology.
• Experience with genomics, functional genetic screens or mouse models of cancer (xenografts, PDXs, GEMMs) may be helpful but not mandatory.
• Computational skills including computer programming are of interest but not mandatory

At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong.?? As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff.?? Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.