Scheduled Hours40Position SummaryThe Diwan laboratory focuses on understanding the role of lysosomes in health and disease. Our lab has uncovered evidence for dysregulation of the lysosome machinery as a major contributor to cardiac myocyte loss in myocardial ischemia-reperfusion injury. Our work has also extended these findings to uncover evidence for lysosome dysfunction in various CNS cell types in Alzheimerâ™s disease and in pancreatic beta cells in obesity-induced diabetes, underscoring the importance of acquired lysosome dysfunction in triggering multiple chronic diseases that are predisposed by common risk factors. Using animal models, the lab is also focused on understanding how lysosome function in oocytes in moms affects cardiac
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