Dr. Vittorio Sebastiano's lab in the Reproductive and Stem Cell Biology, Department of Obstetrics and Gynecology at Stanford University currently has multiple outstanding long-term job opportunities for full-time researchers, Postdoctoral fellows or lab manager. Dr. Sebastiano's lab is investigating various paradigms of nuclear programming and reprogramming with a particular emphasis on the resetting of the epigenetic program of youth in aged human cells. Our research has very important clinical implications in aging, aging-associated diseases, reproductive biology and regenerative medicine. We use human samples collected from patients, mouse models, and organoid cultures. Our group collaborates with multiple departments at Stanford.
The LSRP 2 will help in our mission to understand how reprogramming affects cellular age and cellular identity. This is an exciting opportunity to participate in groundbreaking research as part of a dynamic team. The LSRP 2 will contribute to all aspects of ongoing research projects including collecting samples, conducting experiments, reviewing literature, preparing interpretation and summaries of results, participating in conferences, and lab management duties. Specific responsibilities include: Human and/or mouse sample collection, organoid culture, bacterial co-culture, gene editing, sequencing library preparation, DNA and RNA extraction and quantification, Quantitative PCR, Immunohistochemistry, cell imaging, other cellular and molecular biology techniques. Some mouse experiments may be conducted such as xenograft.
Independently conduct a portion of the research project(s). Make recommendations on experimental design and/or research direction to principal investigator.
Independently conduct complex (lab and/or field) experiments to gather data for a portion of a major research project.
Interpret and analyze results, often where few guidelines exist, and make modifications to existing procedures and protocols.
Develop new research protocols where appropriate protocols are not described in the literature or where modification or adaptation of standard procedures and protocols is required.
Participate in multidisciplinary teams across different faculties or schools.
Perform ongoing literature review to remain current with new procedures and related research; apply to ongoing research and development of new protocols.
Contribute substantively to the preparation of papers for publication, especially in the results section, and to publication of findings. Present ongoing work to colleagues and/or academic conferences.
Oversee supply and equipment budget under supervision of principal investigator or business manager.
Work with health and safety department to ensure lab complies with regulations and all required trainings.
Supervise (either formally or informally) staff or students as needed, including oversight and direction on techniques, as well as consultation on project work. Serve as a technical resource for other research staff.
Oversee the daily activities of the laboratory including lab maintenance; maintain lab stock, manage chemical inventory and safety records, and provide general lab support as needed. May assist with purchasing laboratory equipment.
*- Other duties may also be assigned.
MS or PhD in biological science or technology and a minimum of two years of research laboratory experience.
Prior experience with tissue culture, cellular and molecular biology, and mouse handling is necessary.
Prior experience working with skin (e.g. skin organoids, skin explants), muscle physiology and/or immunology is desired but not necessary.
Prior experience on nuclear reprogramming (iPSCs derivation) is desired.
Ability to work independently and as part of a research team.
Cover letter and at least 3 references are required.
EDUCATION & EXPERIENCE (REQUIRED):
Bachelor's degree in related scientific field and two years of relevant work experience; or Master's degree in a related scientific field.
KNOWLEDGE, SKILLS AND ABILITIES (REQUIRED):
Comprehensive understanding of scientific principles.
General computer skills and ability to quickly learn and master computer programs, databases, and scientific applications.
Strong analytical skills and excellent judgment.
Ability to maintain detailed records of experiments and outcomes.
Ability to work under deadlines with general guidance is essential.
Excellent organizational skills and demonstrated ability to accurately complete detailed work.
Frequently stand, walk, twist, bend, stoop, squat, grasp lightly, use fine manipulation, grasp forcefully, perform desk-based computer tasks, use telephone, write by hand, lift, carry, push and pull objects weighing over 40 pounds.
Occasionally sit, kneel, crawl, reach and work above shoulders, sort and file paperwork or parts.
Rarely climb, scrub, sweep, mop, chop and mix or operate hand and foot controls.
Must have correctible vision to perform duties of the job.
Ability to bend, squat, kneel, stand, reach above shoulder level, and move on hard surfaces for up to eight hours.
Ability to lift heavy objects weighing up to 50 pounds.
Ability to work in a dusty, dirty, and odorous environment.
Position may require repetitive motion.
*- Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of his or her job.
May require working in close proximity to blood borne pathogens.
May require work in an environment where animals are used for teaching and research.
Position may at times require the employee to work with or be in areas where hazardous materials and/or infectious diseases are present.
Employee must perform tasks that require the use of personal protective equipment, such as safety glasses and shoes, protective clothing and gloves, and possibly a respirator.
Requires extended or unusual work hours based on research requirements and business needs.
Interpersonal Skills: Demonstrates the ability to work well with Stanford colleagues and clients and with external organizations.
Promote Culture of Safety: Demonstrates commitment to personal responsibility and value for safety; communicates safety concerns; uses and promotes safe behaviors bases on training and lessons learned.
Subject to and expected to comply with all applicable University policies and procedures, including but not limited to the personnel policies and other policies found in the University's Administrative Guide, http://adminguide.stanford.edu.
Stanford is an equal opportunity employer and all qualified applicants will receive consideration without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status, or any other characteristic protected by law.
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Located between San Francisco and San Jose in the heart of Silicon Valley, Stanford University is recognized as one of the world's leading research and teaching institutions. Leland and Jane Stanford founded the University to "promote the public welfare by exercising an influence on behalf of humanity and civilization." Stanford opened its doors in 1891, and more than a century later, it remains dedicated to finding solutions to the great challenges of the day and to preparing students for leadership in a complex world. The University's thriving diverse community is comprised of nearly 7000 undergraduate students, 12000 graduate students, 2000 faculty members, 1900 postdoctoral scholars, and over 11,000 academic and administrative staff in seven schools including several interdisciplinary research centers and institutes. The campus spreads over 8000 contiguous acres and nearly all undergraduates live on campus. Stanford offers bachelor's and master's degrees in addition to doctoral degrees (PhD, MD, DMA and JD) plus a number of professional and continuing education programs and certifications. More at http://facts.stanford.edu and http://www.stanford.edu. Stanford is an equal empl...oyment opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. Stanford also welcomes applications from others who would bring additional dimensions to the University’s research, teaching and clinical missions.