Are you a hardworking and dedicated research professional interested in being part of breakthrough Research?
When you join Cedars-Sinai, you become part of a team that is at the forefront of medical advancements and life-saving medical and scientific breakthroughs. Cedars-Sinai is one of the leading institutes for driven research funding from the National Institutes of Health. As an international leader in biomedical research, we translate discoveries into successful treatments with global impact.
Principal Investigator, Caroline Jefferies, PhD is searching for a Research Associate III to join the team!
The research of Caroline Jefferies, PhD, is focused on understanding the role that RNA/DNA sensing mechanisms in monocytes and neutrophils play in driving autoimmune disease. The lab's main area of focus is understanding these pathways in lupus, a debilitating, chronic autoimmune disease that presents as a broad spectrum of symptoms and manifestations. You will join a translational immunology lab whose focus is the role of the innate immune system in driving the autoimmune disease Lupus. Your role as a member of this team will contribute to on-going projects, which utilize molecular biology and immunological techniques to address on-going questions in the lab.
Projects you might be involved include:
Understanding what contributes to the development of lung disease or heart disease in Lupus patients;
Understanding how gene expression is regulated in Lupus immune cells;
You will use both animal models and primary immune cells from Lupus patients to address these questions.
Under general guidance, the Research Associate III (RA III) works closely with Principal Investigator, providing technical and/or administrative support in large or multi-project oriented labs. May be requested by PI to take on specific supervisory activities, and provide administrative leadership, and/or technical expertise. May develop hypothesis and assist in planning steps for the investigative process. Will review and remain current on literature as it relates to clinical/research study. Coordinates all lab and/or clinical activities, including but not limited to, budgetary/financial compliance, preparation of grant proposals, and creating independent presentations. Not responsible for generating grant funds.
Primary Duties and Responsibilities:
Provides miscellaneous clinical/research support (ad hoc data analysis, hypothesis development, programming, troubleshooting, etc.).
Organizes clinical/research trials in conjunction with the Principal Investigator and sponsor and/or funding source.
Monitors and ensures compliance with safety standards and procedures.
Analyzes data and prepares scientific findings for publication as author or co-author.
May make independent presentations.
May provide system administration and maintenance for the local workstation network.
Leads and trains Research Lab Assistants, Research Fellow, lower level Research Associates, and other related support staff and may be requested by PI to take on specific supervisory activities.
Orients new Research Fellows and/or Research Scientists to day-to-day lab operations and procedures.
Conducting animal experiments to assess how UV contributes to skin disease in Lupus.
Setting up models to assess skin inflammation in lupus - including air liquid interface cultures, staining biopsies to analyze inflammation.
Using co-immunoprecipitation and western blotting to look at protein-protein interactions and post-translational modifications of proteins.
Other laboratory analysis as appropriate such as RT-PCR, IF, Western blotting.
Bachelor of Science or Bachelor of Arts degree in biological sciences, required.
Master's Degree of Science, preferred.
Three to five (3-5) years of experience in area of research specialization.
Technical skills and expertise in an area of study including, but not limited to, Molecular/Cellular Biology, Neuroscience, engineering, or mass spectometry.
Experience in cutting-edge histology/imaging techniques including quantitative bright-field and fluorescence microscopy, confocal microscopy, and electron microscopy is required.
Strong computer skills (MS Word, MS Excel, MS Access, PowerPoint).
Strong analytical and problem-solving skills; excellent organization skills and very detail-oriented; learns new tasks quickly; self-motivated; works well independently with minimal supervision; works well with others, and able to multitask.
Strong interpersonal skills for interaction with peers, patients, physicians, and other customers of the medical center. Thorough technical and theoretical understanding of PI's research objectives.
Mastery of complex or unusual technical procedures and protocols.
Ability to research, develop and implement new laboratory procedures and protocols. Knowledge of human resource and administration policies and procedures. Knowledge of budgetary requirements and policies.
Working Title: Research Associate III - Rheumatology
Providing healthcare for more than 100 years, Cedars-Sinai has evolved into one of the most dynamic and highly renowned medical centers in the world. Along with caring for patients, Cedars-Sinai is a hub for biomedical research and a training center for future physicians and other healthcare professionals. This attracts exceptional talent to Cedars-Sinai, including world-renowned physician-scientists who seek a place where they can both conduct research and see patients--the ideal formula for discovery and its translation into cures. Our patients benefit from access to doctors at the top of their fields, and our researchers have an ideal community in which to study the impact of healthcare challenges, and reflect that knowledge in their research. The greater Los Angeles area in which Cedars-Sinai resides possesses unparalleled cultural and ethnic diversity which offers outstanding opportunities for translational and clinical research and a dynamic environment for medical education.Although community based, Cedars-Sinai is a major t...eaching hospital affiliated with the David Geffen School of Medicine at the University of California, Los Angeles (UCLA). Cedars-Sinai has highly competitive graduate medical education programs in more than 50 specialty and subspecialty areas, a graduate program in biomedical sciences and translational medicine, a clinical scholars program directed towards junior physicians with aspirations to become clinical scientists, and post graduate training opportunities.There are more than 250 full-time faculty members at Cedars-Sinai. The voluntary medical staff, comprised of more than 2,200 specialty board-certified or board-qualified physicians, represent all of the specialties and subspecialties and collaborate with full-time medical staff in the teaching responsibilities of the graduate medical education programs.