We at the Knight Cancer Institute are driven to cure cancer.So, if youre innately inquisitive, motivated, and truly want to explore new opportunities that seek to make a real difference in the way we treat cancer, then this opportunity may be right for you:
We are seeking a Senior Research Assistant to work at the intersection of biomedical data science and cancer metabolic reprograming that occurs during cancer treatment as part of the Thomas Lab . Specifically, we seek to identify metabolic vulnerabilities that occur under selective pressure of treatment, which can then be exploited to eliminate tumor cells. Previous publications from our group include: Genes & Development 20, 2067-2084; Metabolites 5, 82; Cell 174: 758-769; Nature Medicine 12,122-127; Cancer Journal 15, 406-420; Science Translational Medicine 3(85): 85ra47; J Clin Oncol 36: 2492-2503; Cell Rep Med 2, 100267.
The successful candidate will be creative and driven; able to analyze and apply computational tools to emerging genomic technologies to address basic and translational questions in our research area, including cancer metabolism, cancer therapeutics and biomarker discovery. Important findings will be further explored experimentally, both in our lab and through collaboration, with the ultimate goal of translating promising findings into clinical trials. We are looking for a highly-motivated individual, with a basic background in molecular/cellular biology and mathematics (single-variable calculus), who has a strong desire to learn and integrate biological and computational modeling techniques.
Data analysis using bioinformatics software
Performs basic molecular biology techniques including functional cell assays, PCR, Q-PCR, cellular imaging, DNA/RNA extraction, Western blots, etc.
Performs cell culture including drug treatments Assists in the development of new assays in clinical samples
Bachelors Degree (4 yr.) with major courses in molecular and cell biology or related field and at least 1 year of relevant laboratory experience.
Job- related knowledge, skills and abilities:
Computer programming skills (Python, R)
Ability to conduct wet lab experiments with technologies commonly used in molecular labs (ex. cell culture, Westerns, Q-PCR, DNA/RNA/Protein prep)
Laboratory management including overall lab operations, order supplies, maintaining equipment, establish professional relationships with collaborators
Perform cell culture, cellular assays, including immunohistochemistry and IF techniques.
Ability to understand research protocols and take initiative in researching, creating and troubleshooting laboratory techniques
Ability to manage time effectively by prioritizing tasks and multi-tasking efficiently.
Proficient in preparing stock reagents and drug titrations.
Must have excellent communication, analytical and organizational skills: both written and verbal.
Ability to work independently and as part of a team while being collaborative in resolving problems.
Must be proficient with computers running Windows and PC applications e.g. MS Excel, Oracle, Access, Word and PowerPoint).
Highly motivated and committed to academic biomedical research
Bachelor's degree in molecular and cell biology
1-2 years of research and/or laboratory management experience in cell and molecular biology
Flow cytometry experience
Cell culture experience
Experience with research software applications (Prism, XLfit, etc)
Experience with handling and working with mice
Able to write R or Python scripts
Experience using Oracle
Oregon Health & Science University values a diverse and culturally competent workforce. We are proud of our commitment to being an equal opportunity, affirmative action organization that does not discriminate against applicants on the basis of any protected class status, including disability status and protected veteran status. Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. To request reasonable accommodation contact the Affirmative Action and Equal Opportunity Department at 503-494-5148 or email@example.com.
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