Post-Doctoral Fellow at Duke - Gene Therapy for Respiratory Dysfunction in DMD
Our lab is focused on gene therapy and the control of breathing in neuromuscular disorders. Specifically, we study mouse models of Amylotrophic Lateral Sclerosis, Pompe disease and Duchenne Muscular Dystrophy. In addition, we evaluate the efficacy of adeno-associated viral-mediated gene therapy to correct the respiratory insufficiency that results from these neuromuscular disorders. Specific functions we test are whole body plethysmography and neurophysiology, which measure the muscular and neurological inputs that enable breathing. We also work with neuronal cell cultures. Post-mortem molecular analysis is also employed, including biochemical (qPCR and western blot) and histological techniques. As a clinician scientist, Dr. ElMallah’s goal is to bring therapy form the bench
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