This position will remain open until a successful candidate has been identified.
UCSD Layoff from Career Appointment: Apply by 07/07/21 for consideration with preference for rehire. All layoff applicants should contact their Employment Advisor.
Special Selection Applicants: Apply by 07/15/21. Eligible Special Selection clients should contact their Disability Counselor for assistance.
The Moores Cancer Center is one of just 51 in the United States to hold a National Cancer Institute (NCI) designation as a Comprehensive Cancer Center. As such, it ranks among the top centers in the nation conducting basic and clinical cancer research, providing advanced patient care and serving the community through outreach and education programs. The Cancer Center's mission is to translate promising scientific discoveries into new and better options for the care of patients with cancer. The Center supports one of the broadest ranges of cancer activities in the nation – from fundamental and translational cancer research in molecular genetics and advanced molecular therapeutics, and from population studies of cancer incidence to community education about cancer prevention and risk reduction.
The Genomics and Laboratory Research Associate will be expected to contribute to the independent design, conduct, and analysis of experiments and their results and also preparation, presentation, and publication of results under the direction of the Principal Investigator (PI). Make significant innovative contributions pertaining to the design and overall direction of scientific research projects and propose possible changes or new directions in the course of the investigations. Read and evaluate scientific articles relevant to current research studies, finding new sources of information. The incumbent will be responsible for applying or adapting scientific techniques and assisting with the planning and scheduling of research procedures, recording the results of studies, compiling and analyzing data including statistical analyses, and preparing charts, graphs and presentations.
Scientific intellect especially as it pertains to cancer molecular biology and computational genomics is essential. Experience with bioinformatic tools and programming experience is also essential for analysis of high throughput genomic sequencing data. Work will include sequencing alignment, analysis, comparative statistics and algorithm development. Responsibilities will also include cell culture, growth and migration assays, isolation of nucleic acids and proteins, and quantitative analysis with PCR. Lastly immunologic correlates including EliSPOT assays and T-cell reactivity assays will be evaluated in relationship to genomic alterations. The incumbent will be working with murine animal models, maintain animal colony, maintain laboratory equipment, order supplies as needed and assist laboratory management to provide support for students, postdocs and general laboratory operations.
Our research work seeks to understand post transcriptional changes, including alternative splicing events, which are prevalent in head and neck cancer. We utilize computational biology methods to achieve a deeper understanding of these post transcriptional genomic alterations that are not readily apparent through sequencing alone. Splicing alteration and post transcriptional alterations represent an understudied gap in genomic knowledge that seeks to understand changes that occur between DNA mutations and ultimately expressed protein phenotypes in tumors. By harnessing computational tools, we can come closer to translating this genomic knowledge towards the delivery of precision cancer care in head and neck cancer. Other duties assigned as needed.
Advanced theoretical knowledge and/or Bachelor's Degree in molecular biology, and/or related work experience.
Proven experience with bioinformatic analysis including proficiency in use of R.
Demonstrated experience performing RNA and protein isolation.
Experience performing sterile eukaryotic cell culture techniques, PCR and agarose gel electrophoresis.
Experience handling and working with small animals, including demonstrated experience conducting mouse surgeries, experiments, and injections. Knowledge in conducting euthanization of small animals.
Strong experience and knowledge in coordinating major mouse experiments, such as planning injection and drug treatment dosing schedule.
Experience with protein biochemistry techniques; including quantification, ELISA assays, SDS PAGE, Western and Immunoblotting, phosphorylations and gel electrophoresis.
Detail-oriented. Ability to follow verbal and/or written
UC San Diego is an academic powerhouse and economic engine, recognized as one of the top 8 public universities by U.S. News and World Report. Innovation is central to who we are and what we do. Here, students learn that knowledge isn't just acquired in the classroom - life is their laboratory. UC San Diego's rich academic portfolio includes six undergraduate colleges, five academic divisions and five graduate and professional schools. The university's award-winning scholars are experts at the forefront of their fields with an impressive track record for achieving scientific, medical and technological breakthroughs.