Area of specialization/responsibilities include: Incumbent will pursue several projects related to the growing concerns of cardiovascular toxicities associated with cancer immunotherapies. An important focus in the laboratory for the last several years has been generation of mouse models that replicate ICI-associated myocarditis, a new form of myocarditis that our group initially described (Johnson et al, NEJM, 2016; Moslehi et al, Lancet, 2018). The incumbent will help in better characterizing the immune cells that drive this form of myocarditis. The incumbent will also ask if these immune cells are necessary and sufficient for this development of myocarditis. In addition, in collaborative work with Dr. Balko at Vanderbilt, the incumbent will further work to determine the antigenic drivers of myocarditis. Techniques will include myocardial injury models, mouse echocardiography, various molecular biology techniques, as well as flow cytometry. These experiments will test the hypothesis that targets of immunotherapies (e.g., PD-1) have a fundamental role in cardiovascular homeostasis. The incumbent will also apply bioinformatic tools to better define inflammatory cardiomyopathies in general.
Required qualifications: • PhD in molecular biology or related topic • At least 3-years of experience working in a research laboratory in either academia or industry settings. • Ability to perform regular drug delivery via intraperitoneal (IP) injection or oral gavage. • Ability to collect serum from mice. • Experience with molecular biology software (e.g., SnapGene or MacVector). • Experience preparing, submitting, and analyzing DNA sequencing data from Sanger sequencing. • Experience with cardiac cell isolation via Langendorff perfusion. • Knowledge of cell culture, standard molecular biology and biochemistry techniques, and in vivo mouse modeling. • Demonstrated ability to contribute data to ongoing research efforts. • Skill in independently resolving broad problems that may arise in collection or analysis of laboratory data. • Self-motivated with ability to work independently and as part of a team. • Able to learn effectively and meet deadlines. • Demonstrated experience and ability to collaborate effectively with all levels of staff. • Demonstrated effective communication and interpersonal skills. • Proven ability to successfully work on multiple concurrent projects. • Highest level of integrity and professionalism in working with patient data in a HIPAA-compliant and ethically responsible manner. • Ability to effectively manage time. • Prior publications in the field of cardiovascular biology. • Knowledge of cardiovascular development and adult cardiovascular pathologies including surgical procedures regularly performed on cardiac patients. • Demonstrated ability to regularly interface with multiple colleagues on a variety of different research programs simultaneously. • Proven ability to understand research cycles and rapidly perform experiments necessary for manuscripts in revision. • Interest and proven ability to work closely with other members of the team towards carrying out the broader goals of the laboratory. • Self-motivated and able to learn quickly.
Appointees in the Specialist series will be expected to engage in specialized research, professional activities and do not have teaching responsibilities. Specialists are expected to use their professional expertise to make scientific and scholarly contributions, and may participate in University and Public Service. Screening of applicants will begin immediately and will continue as needed throughout the recruitment period. Salary and rank will be commensurate with the applicants experience and training.
UC San Francisco seeks candidates whose experience, teaching, research, or community service has prepared them to contribute to our commitment to diversity and excellence. The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status.
The University of California, San Francisco (UCSF) is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and high-quality patient care. It is the only UC campus in the 10-campus system dedicated exclusively to the health sciences.