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Application Review Date
The First Review Date for this job is: March 26, 2021
The Department of Molecular & Cell Biology (MCB) is home to undergraduate and graduate academic programs as well as Faculty Research performed by faculty organized in five divisions:
Biochemistry, Biophysics and Structural Biology
Cell and Developmental Biology
Genetics, Genomics and Development
Immunology and Pathogenesis
The teaching and research activities of the Department of Molecular and Cell Biology (MCB) concern the molecular structures and processes of cellular life and their roles in the function, reproduction, and development of living organisms. This agenda covers a broad range of specialized disciplines, including biochemistry, biophysics, molecular biology, structural biology, genetics, genomics, bioinformatics, cell biology, developmental biology, tumor biology, microbiology, immunology, pathogenesis and neurobiology. The types of living organisms from which the departmental faculty draws its working materials are as diverse as its disciplinary specializations, ranging from viruses and microbes through plants, roundworms, annelids, arthropods, and mollusks to fish, amphibia, and mammals. The faculty of the department is organized into five divisions: Biochemistry and Molecular Biology; Cell and Developmental Biology; Genetics, Genomics and Development; Neurobiology; and Immunology and Pathogenesis.
Now's your chance to join our team developing cutting edge optogenetic treatments and cures for vision loss and blindness. We have restored vision to genetically blind mice! By expressing light sensitive proteins, called opsins, in their eyes, these mice can now discriminate objects and move about a room.. While the first of these systems is moving into clinical trials, we continue to develop new tools aimed at increasing light sensitivity and acuity. If you have experience with mouse behavior and learning models, we need your help in testing vision restoration.
Learning and Behavior Tasks:
Plan and setup experiments in collaboration with senior team members.
Modify tasks and develop new paradigms as required with input from PI and senior team members.
May require purchase, assembly and/or testing of equipment as well as learning of equipment specific software packages.
Data Collection and Analysis:
Collect and record data in notebook and transfer to spreadsheet such as Excel.
Statistical analysis using standard tests such as student's ttest.
Assist in preparation of data for figures using Adobe Illustrator.
Conduct intravitreal and subretinal injections, monitor animal recovery and health.
May be required to monitor expression via RetCam.
Requires controlled substances certification and work with multiple viral models.
Isolate, dissect, and section tissue, analyze expression via microscopy or prepare for Multi Electrode Array (MEA) study.
Animal Husbandry and Colony Management:
Perform breeding, weaning, health monitoring, and record keeping, producing required number of animals for each experiment.
Develop and maintain required animal use databases.
Comfort or experience handling mice and rats.
Ability to maintain clean, well-organized workspace and detailed lab notebook.
Good interpersonal skills essential.
Ability to pass background check for use of controlled substances.
Ability to perform subretinal and intravitreal injections.
Experience in animal behavioral testing and ability to develop, troubleshoot, and perform behavioral testing and independently assess vision restoration in test rodents.
May require weekend hours and/or afternoon shifts
BS in Biology and/or equivalent experience/training.
Basic neurobiology knowledge.
Experience in basic animal physiology.
Working knowledge of retina and visual system.
Basic knowledge of statistics and data analysis and spreadsheets.
Ability to learn, trouble shoot, and modify multiple behavior based software packages.
Ability to assemble complex behavior apparatus, include software trouble shooting and basic electronics assembly.
Familiarity with Retcam, Mult-electrode Array (MEA), and vibratome.
Salary & Benefits
This position is a non-exempt, bi-weekly paid position. Hourly pay for this role is commensurate with experience.
For information on the comprehensive benefits package offered by the University visit:
The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or protected veteran status. For more information about your rights as an applicant see:
The University of California was chartered in 1868 and its flagship campus - envisioned as a "City of Learning" - was established at Berkeley, on San Francisco Bay. Today the world's premier public university and a wellspring of innovation, UC Berkeley occupies a 1,232 acre campus with a sylvan 178-acre central core. From this home its academic community makes key contributions to the economic and social well-being of the Bay Area, California, and the nation.