Postdoctoral Scientist - Non-classical mechanisms of therapy resistance, Cancer Institute
Cedars-Sinai Medical Center
Location: Los Angeles, California
Internal Number: HRC0118188C
When the work you do every single day has a crucial impact on the lives of others, every effort, every detail, and every second matters. This shared culture of happiness, passion, and dedication pulses through Cedars-Sinai, and it's just one of the many reasons why we rank as one of the top hospitals in the nation by U.S. News & World Report.
Are you ready to be a part of breakthrough research?
In this role, the Postdoctoral Scientist will be expected to work independently under the direction of the Principal Investigator (P.I.) and in close cooperation, as well as consultation, with other research staff.
Dr. Keith Syson Chan's laboratory is seeking a postdoctoral scientist to investigate non-classical mechanisms of therapy resistance, including but not limited to cell death-induced cancer stem cell repopulation [ Nature 517, 209-213(2015) https://rdcu.be/cikEy ], and immunosuppression [ Nature Communications 11: 6299 (2020) https://rdcu.be/cikEQ ]. This project will study cancer stem cells and differentiated cells by single cell real-time imaging and other single cell molecular technologies to dissect their epigenetic regulation during tumor repopulation and therapy resistance.
Ideal applicant will be a self-motivated individual who is enthusiastic to interact with other lab members and the PI, he/she is most welcome to bring new ideas to drive project directions. Expertise in epigenetic regulation of normal or cancer stem cells, with extensive experience in FACS, molecular biology knowledge in constructing lentiviral vectors, and organoid culture highly preferred.
KS Chan lab is comprised of an interdisciplinary team https://www.research4cure.org , focusing on cancer research that can translate into early-phase clinical trials or biomarkers to impact patients. We integrate cutting edge single-cell technologies and various study models (e.g., patient-derived xenografts, syngeneic murine models, GEMM) to address key research questions spanning: i) cell death-induced non-classical mechanisms of therapeutic resistance, ii) primary tumor and metastatic niche, and iii) emerging immunologic concepts that impact tumor progression and immune checkpoint response.
The design of research directions and experiments in cooperation with the mentor. Will keep appropriate experimental records and analyze the results with the PI. Typical daily experimental activities include FACS, 2D/3D culture, animal models and drug treatment studies.
Explore literature and state-of-the-art techniques relevant to the project.
Compile figures and text for the submission of publications and presentations as primary author or co-author.
Highly encouraged to apply for fellowship or career transition grant application for career advancement.
Participate and present at lab meetings, research-oriented interest groups, and attend departmental or cancer center seminar series
Doctorate (MD, PhD, VMD, or DDS) in biomedical sciences, cancer biology or immunology.
Ph.D. or equivalent doctorate within previous three year
Please apply online AND send a cover letter/personal statement + CV to Dr. Chan @ KeithSyson.Chan@cshs.org
Working Title: Postdoctoral Scientist - Non-classical mechanisms of therapy resistance, Cancer Institute
Providing healthcare for more than 100 years, Cedars-Sinai has evolved into one of the most dynamic and highly renowned medical centers in the world. Along with caring for patients, Cedars-Sinai is a hub for biomedical research and a training center for future physicians and other healthcare professionals. This attracts exceptional talent to Cedars-Sinai, including world-renowned physician-scientists who seek a place where they can both conduct research and see patients--the ideal formula for discovery and its translation into cures. Our patients benefit from access to doctors at the top of their fields, and our researchers have an ideal community in which to study the impact of healthcare challenges, and reflect that knowledge in their research. The greater Los Angeles area in which Cedars-Sinai resides possesses unparalleled cultural and ethnic diversity which offers outstanding opportunities for translational and clinical research and a dynamic environment for medical education.Although community based, Cedars-Sinai is a major t...eaching hospital affiliated with the David Geffen School of Medicine at the University of California, Los Angeles (UCLA). Cedars-Sinai has highly competitive graduate medical education programs in more than 50 specialty and subspecialty areas, a graduate program in biomedical sciences and translational medicine, a clinical scholars program directed towards junior physicians with aspirations to become clinical scientists, and post graduate training opportunities.There are more than 250 full-time faculty members at Cedars-Sinai. The voluntary medical staff, comprised of more than 2,200 specialty board-certified or board-qualified physicians, represent all of the specialties and subspecialties and collaborate with full-time medical staff in the teaching responsibilities of the graduate medical education programs.