Cancer Early Detection Advanced Research (CEDAR) center is a collaborative institution within the OHSU Knight Cancer Institute. The Knight Cancer Institute, known as one of the pioneers in personalized cancer medicine, is an international leader in research and cancer treatment. At CEDAR our mission is to detect and stop lethal cancers at the earliest stage because early detection saves lives. This is an ambitious goal, one that requires novelty, creativity, and innovation. We are composed of biologists, chemists, biomedical engineers, computationalists, and clinicians conducting groundbreaking translational cancer research to help people maintain a high quality of life and reduce cancer mortality, to create a global early detection community, and to have a positive impact on the Oregon economy.
CEDAR is committed to increasing the diversity of the campus community. We at CEDAR are dedicated to promoting inclusion and multiculturalism to build a successful organization by having outstanding researchers of diverse backgrounds work together on multiple projects. We encourage high-risk, high-reward research projects because defeating cancer requires unproven, out-of-the-box thinking. Our research is milestone driven to ensure that each project is fulfilling its stated goals.
Every Knight Cancer employee is expected to embody our guiding principles:
We act BOLDLYBreakthroughs require pushing the boundaries of science, exploring new frontiers, and thinking differently
We SUPPORT each otherRespect leads to trust, which leads to excellence
We work as a CONNECTED teamWe must leverage our collective brain power to conquer cancer because no one individual can do it alone
We are currently hiring at the level of Senior Research Assistant with expertise in Computational Biology to will use both existing tools and develop their own computational methods to analyze multiomic datasets for characterization of healthy and cancerous cell populations. In this role you will work on project teams working on using NMT-seq and other scRNAseq methodologies which allows profiling of the transcriptome, chromatin accessibility, and methylation at the single cell level to identify signals that drive heterogeneity in early cancer. Using this method and others, we will track tumor evolution at the genetic and epigenetic level.
Data Organization and Management
Clean and manage metadata
Access, store, and document raw data
Coordinate with project team members
Meet publication requirements, including data and code repositing
Develop novel analyses and visualizations
Implement existing analytic packages and workflows
Creatively adapt existing resources as needed to meet project needs
Sample/sequencing quality control assessment
Present at regular team meetings
Clear code documentation
Support manuscript preparation
Support grant writing efforts
Multi-omics profiling of mouse gastrulation at single-cell resolution. Argelaguet R, Clark SJ, Mohammed H ., Nature, 2019, 576;487491
scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells. Clark SJ et al., Nat Commun, 2018, 22;9(1):781
Bachelors Degree (4 yr) with major courses in field of research and 1 to 3 years of relevant experience
Experience developing novel analyses and visualizations and adapting exiting recousces
Programming experience with python/R or equivalent programming language
Experience in working with existing software for the analysis of next generation sequencing genomics data such as RNA-seq, including their single-cell versions
Excellent communication, analytical and organizational skills
Ability to work independently and as part of a team while being collaborative in resolving problems
Ability to prioritize multiple tasks at one time
Must possess energy and drive to coordinate multiple projects simultaneously
Ability to use tact and diplomacy to maintain effective working relationships
Demonstrated ability to learn new and innovative processes quickly
Masters degree in computation or statistics and 3 years of experience
Understanding of cell biology
Ability to clearly communicate and collaborate with researchers from diverse backgrounds, including wet-lab scientists
Experience in a collaborative or team science based environment
Experience in user friendly software development, maintenance, and version control
Apply online. Please be sure to upload a Cover Letter and Resume/CV.
Oregon Health & Science University values a diverse and culturally competent workforce. We are proud of our commitment to being an equal opportunity, affirmative action organization that does not discriminate against applicants on the basis of any protected class status, including disability status and protected veteran status. Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. To request reasonable accommodation contact the Affirmative Action and Equal Opportunity Department at 503-494-5148 or email@example.com.
As the state's only health and research university, OHSU brings together patient care, research, education of the next generation of health care providers and scientists and community service to improve the health and well-being of all Oregonians.The university is a conduit for learning for more than 2,800 students, providing training to interns, residents and fellows in postgraduate medical and research. It is the only place in Oregon that grants doctoral degrees in medicine, dentistry and nursing. OHSU cares for more than 251,000 patients each year from around the region and takes a leadership role in contributing to solutions involving the health of the state and the nation, such as health care access and transparency, ethics and workforce shortage. Beyond providing critical health care services, quality education and cutting-edge research, OHSU also is a key economic and social force in the Northwest. With an annual operating budget of $2.06 billion and more than 14,000 employees, OHSU is Portland?s largest employer. Its size contributes to its ability to provide... many services and community support activities not found anywhere else in Oregon. For more information visit http://www.ohsu.edu/xd/about/index.cfm