An opportunity is immediately available for a Postdoctoral Research Associate at the Washington University Division of Nephrology. Endoplasmic reticulum (ER) dysfunction and protein misfolding disease is an emerging field. The overall goals of our research are to delineate the molecular mechanisms underlying ER stress-mediated kidney diseases, including nephrotic syndrome (NS), Alport syndrome, autosomal dominant tubulointerstitial kidney disease (ADTKD), acute ischemic kidney injury, and other acquired forms of ER disease, to develop ER stress biomarkers in human patients, and to identify ER stress modulators. The posted position will focus on mechanism investigation, novel signaling pathway identification and therapeutic intervention in the area of podocyte ER stress and ER calcium dyshomeostasis (Proc Natl Acad Sci 116: 14154-14163, 2019; JCI Insight 2(23): e92896 2017; J Am Soc Nephrol 27: 2974-2982 2016; J Am Soc Nephrol 24: 1223-1233 2013; one issued patent related to the discovery of two ER stress biomarkers).
We are using cutting-edge research approaches, including stably transfected or knock-down cells, molecular and cell biology, biochemistry, inducible transgenic, conditional knock-out and CRISPR generated knock-in mouse models, human iPSCs derived from patients, and state-of-the-art in vitro and in vivo imaging techniques. We also have access to multiple kidney disease consortiums to acquire their genomic data, gene expression, histology from kidney biopsies, and urine samples. The PI's research has been funded by multiple grants from NIH, Department of Defense, industry, etc. The lab environment is highly supportive.
A PhD or MD/PhD degree in biochemistry, molecular biology, molecular genetics or other related fields.
A strong background in molecular biology or biochemistry.
Experience with ER or podocyte biology, mouse genetic models, or kidney-related research is highly desired.
Base pay commensurate with experience.
Applicant Special Instructions
Interested candidates should email a CV, cover letter and the names of three references to:
Maggie Chen, MD, PhD
Associate Professor of Medicine
Director, Nephrotic Syndrome Clinic Division of Nephrology
Washington University School of Medicine
660 S. Euclid Avenue
St. Louis, MO 63110
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.
Washington University in St. Louis is committed to providing a comprehensive and competitive benefits package to our employees. Benefits eligibility is subject to employment status, full-time equivalent (FTE) workload, and weekly standard hours. Please visit our website at https://hr.wustl.edu/benefits/ to view a summary of benefits.
Washington University is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration without regard to an individualâ™s sex, race, color, religion, age, disability status, protected veteran status, national or ethnic origin, gender identity or expression, sexual orientation. Women, minorities, protected veterans and the disabled are strongly encouraged to apply.
Washington University is dedicated to building a diverse community of individuals who are committed to contributing to an inclusive environment â“ fostering respect for all and welcoming individuals from diverse backgrounds, experiences and perspectives. Individuals with a commitment to these values are encouraged to apply.
Washington University in St. Louis, a medium-sized, independent university, is dedicated to challenging its faculty and students alike to seek new knowledge and greater understanding of an ever-changing, multicultural world. The University offers more than 90 programs and almost 1,500 courses leading to bachelor's, master's and doctoral degrees in a broad spectrum of traditional and interdisciplinary fields, with additional opportunities for minor concentrations and individualized programs. The faculty is composed of scholars, scientists, artists and members of the learned professions. They serve society by teaching; by adding to the store of human art, creativity, understanding, and wisdom; and by providing direct services, such as health care.