A postdoctoral position is available in the Division of Cardiology, Department of Medicine at the University of Washington to develop gene therapy for atherosclerosis.
This is a full-time Postdoctoral Scholar position on an annual,12-month appointment (service period July 1-June 30) with an anticipated start date of September 1, 2021. Postdoctoral scholars are represented by UAW 4121 and are subject to the collective bargaining agreement, unless agreed exclusion criteria apply. For more information, please visit the University of Washington Labor Relations website.
The project aims to develop gene therapy that prevents or reverses atherosclerosis by increasing expression of atheroprotective genes in the blood vessel wall. Therapeutic genes encode secreted and cell-surface proteins (PMID 29122817 and 30079772) as well as antagomiRs (PMID 31842627), all aimed at decreasing vascular lipid accumulation and inflammation. This NIH-funded project builds on many years of work—including numerous publications—and will extend our finding that helper-dependent adenoviral vectors are particularly effective agents for in vivo vascular gene transfer and gene therapy (PMID 15326058). The approach uses rabbit atherosclerosis models (PMID 12149463 and 29296626) and is expected to yield preclinical data for a human gene therapy trial. Interest in experimental atherosclerosis is essential. Experience with adenovirus is desirable, but not required. Basic knowledge and hands-on experience in molecular biology, protein chemistry, and histology are helpful.
The University of Washington is a rich environment for research in cardiovascular biology and disease. Seattle is a pleasant place to live.
The successful candidate must have a Ph.D. or foreign equivalent degree relevant to biological science and a strong publication record, including first-authorships.
Ph.D. or foreign equivalent degree relevant to biological science and a strong publication record, including first-authorships.
Please submit a cover letter and CV as well as the names/emails for three references through Interfolio. With questions, you may contact David Dichek, M.D., Division of Cardiology, University of Washington, firstname.lastname@example.org
University of Washington is an affirmative action and equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, creed, religion, national origin, sex, sexual orientation, marital status, pregnancy, genetic information, gender identity or expression, age, disability, or protected veteran status.
Founded in 1861, the University of Washington is one of the oldest public institutions in the west coast and one of the preeminent research universities in the world. The University of Washington is a multi-campus university comprised of three different campuses: Seattle, Tacoma, and Bothell. The Seattle campus is made up of sixteen schools and colleges that serve students ranging from an undergraduate level to a doctoral level. The university is home to world-class libraries, arts, music, drama, and sports, as well as the highest quality medical care in Washington State and a world-class academic medical center. The teaching and research of the University’s many professional schools provide undergraduate and graduate students the education necessary toward achieving an excellence that will serve the state, the region, and the nation. As part of a large and diverse community, the University of Washington serves more students than any other institution in the Northwest.