When the work you do every single day has a crucial impact on the lives of others, every effort, every detail, and every second matters. This shared culture of happiness, passion, and dedication pulses through Cedars-Sinai, and it's just one of the many reasons we rank as one of the top hospitals in the nation by U.S. News & World Report. From working with a team of committed healthcare professionals to using state-of-the-art facilities, you'll have everything necessary do something incredible--for yourself and for others!
Are you passionate about applying genomics, computer science, and probability theory to study cancer progression?
As part of the Center for Bioinformatics and Functional Genomics at Cedars-Sinai Medical Institute, the Knott Lab focuses on developing molecular and computational tools for analyzing single cell and CRISPR screening data. Our goal is to elucidate the techniques that cancer cells employ to metastasize and evade therapy. To learn more, please visit: https://www.cedars-sinai.org/research/labs/knott.html
The Knott Laboratory at Cedars-Sinai Medical Center is seeking to hire a highly motivated computational scientist to fill the position of Research Bioinformatician I. This position provides excellent opportunities for continued scientific development and contributions at the interface between research and clinical translation in dynamic laboratory environments. Both the Knott laboratory utilizes human samples and mouse models to generate multi-omic datasets using single-cell RNA- and ATAC-seq, ChIPseq, Proteomics, Spatial Transcriptomics and Functional Genomics. The ultimate goal is to integrate these data to provide deeper knowledge of the interplay between the tumor and its immune microenvironment and how these interactions provide support of tumor evolution via plasticity, metastatic progression, and therapy resistance. The Research Bioinformatician will be a critical team member that provides data that will inform follow-up functional validation experiments that provide important rationale for the initiation of first in human clinical trials.
Primary Job Duties & Responsibilities:
Provides general bioinformatics analysis support for omic projects and mainly responsible for data analysis and software compilations including next generation sequence alignment, polymorphism identification, expression analysis, and visualization tools and browsers.
Summarizes data analyses results in the form suitable as the basis for the first draft of written reports, and makes preliminary interpretations of the data.
Assists in development, testing, and maintenance of modular software pipelines for genome sequencing, assembly, annotation, metagenomic analysis, and genotyping using high-throughput sequencing platforms including 454, Illumina, and Pacific Biosciences
Manages data including loading and querying data from database systems, downloading omic data from public repositories, and transforming data to the necessary formats
Helps to identify, evaluate, and incorporate relevant algorithms and software pipelines by reviewing pertinent literatures in bioinformatics and computational biology
Department-Specific Duties & Responsibilities:
Data analysis, integration, and interpretation of data
Management of data-sets
Interact with our bench collaborators to guide and propose new experiments
Participate and present research outputs in group meetings, collaborative meetings, project retreats and seminars
Assists with grant applications and annual grant reports
Bachelor's Degree in Computer Science, Bioinformatics, Statistics or a related field. Working understanding of cell biology, required. Master of Science, preferred.
Experience and Skillset:
0 - 3 years in a research environment
Background and work knowledge in algorithms, scientific computing, and machine learning or statistics. Strong background in R or Python.
Working understanding of cell biology.
Proficient in database management, high performance computing, and the analysis of high throughput data.
Providing healthcare for more than 100 years, Cedars-Sinai has evolved into one of the most dynamic and highly renowned medical centers in the world. Along with caring for patients, Cedars-Sinai is a hub for biomedical research and a training center for future physicians and other healthcare professionals. This attracts exceptional talent to Cedars-Sinai, including world-renowned physician-scientists who seek a place where they can both conduct research and see patients--the ideal formula for discovery and its translation into cures. Our patients benefit from access to doctors at the top of their fields, and our researchers have an ideal community in which to study the impact of healthcare challenges, and reflect that knowledge in their research. The greater Los Angeles area in which Cedars-Sinai resides possesses unparalleled cultural and ethnic diversity which offers outstanding opportunities for translational and clinical research and a dynamic environment for medical education.Although community based, Cedars-Sinai is a major t...eaching hospital affiliated with the David Geffen School of Medicine at the University of California, Los Angeles (UCLA). Cedars-Sinai has highly competitive graduate medical education programs in more than 50 specialty and subspecialty areas, a graduate program in biomedical sciences and translational medicine, a clinical scholars program directed towards junior physicians with aspirations to become clinical scientists, and post graduate training opportunities.There are more than 250 full-time faculty members at Cedars-Sinai. The voluntary medical staff, comprised of more than 2,200 specialty board-certified or board-qualified physicians, represent all of the specialties and subspecialties and collaborate with full-time medical staff in the teaching responsibilities of the graduate medical education programs.