The Center for Bioinformatics and Functional Genomics at Cedars-Sinai Medical Center is seeking a Research Associate III to join the labs of Drs. Simon Gayther and Simon Knott!
The Gayther and Knott laboratories at Cedars-Sinai Medical Center in Los Angeles are searching for a motivated Research Associate to develop and perform high-throughput functional genomic screens with the goal of elucidating how inherited and somatic genomic alterations affect cancer progression and drug response. The candidate will work alongside other wet lab and computational scientists to develop target lists for these screening efforts, construct corresponding CRISPR reagents, perform screens and then help plan and carry out follow up experiments to validate the screen hits and assign them mechanistic context. Candidates should be proficient with cell culture, virus production and infections, DNA and RNA extractions, PCRs and next generation sequencing library generation. Though not a requirement, experience performing high-throughput screens is highly preferred. To learn more, please visit: Gayther Research Lab | Cedars-Sinai (cedars-sinai.edu)
Under general guidance, the RA III works closely with PI, providing technical and/or administrative support in large or multi-project-oriented labs. May be requested by PI to take on specific supervisory activities, and provide administrative leadership, and/or technical expertise. May develop hypothesis and assist in planning steps for the investigative process. Will review and remain current on literature as it relates to clinical/research study. Coordinates all lab and/or clinical activities, including but not limited to, budgetary/financial compliance, preparation of grant proposals, and creating independent presentations. Not responsible for generating grant funds.
Primary Job Duties and Responsibilities:
Undertakes research projects under the direction of the Principal Investigator or other designated investigators in the research team.
Assists in monitoring and ensuring compliance with safety standards and procedures
Assists with analyzing data and preparation of scientific findings for publication and presentations
Contributes to research discussion from other members of the research team
Implements and optimizes new laboratory methods under supervision of designated investigator
Abides by IRB proposals, Animal Licenses, and protocols relating to projects in the laboratory
May make independent presentations.
May provide system administration and maintenance for the local workstation network.
Leads and trains Research Lab Assistants, Research Fellow, lower level Research Associates, and other related support staff.
Orients new Research Fellows and/or Research Scientists to day-to-day lab operations and procedures.
Minimum of a Bachelor of Science degree required. Master of Science degree preferred.
Experience and Skillset:
Three to five (3-5) years of experience in area of research specialization.
Technical skills and expertise in specified areas of study including RNA, DNA and protein-related work, cell culture, and molecular biology (e.g. PCR, cloning) are required.
Expertise in computational analyses, animal modeling of disease or histology is preferred.
Ideal candidate will have strong analytical and problem-solving skills, excellent organization skills and be very detail oriented. The candidate should be self-motivated and able to multitask.
Able to work closely and effectively both within a team environment and also independently on specified projects.
Strong interpersonal skills for interaction with peers and other scientists in the research team as well as with the administrative team within the Center.
Required to have a good technical and theoretical understanding of Principal's Investigators research objectives and the ability to research, develop and implement new laboratory procedures and protocols.
Experience in cell culture.
Strong computer skills (MS Word, MS Excel, MS Access, PowerPoint).
Knowledge of human resource and administration policies and procedures.
Knowledge of budgetary requirements and policies.
Experience in cutting-edge histology/imaging techniques including quantitative bright-field and fluorescence microscopy, confocal microscopy, and electron microscopy is required.
Mastery of complex or unusual technical procedures and protocols.
Working Title: Research Associate III - Bioinformatics
Providing healthcare for more than 100 years, Cedars-Sinai has evolved into one of the most dynamic and highly renowned medical centers in the world. Along with caring for patients, Cedars-Sinai is a hub for biomedical research and a training center for future physicians and other healthcare professionals. This attracts exceptional talent to Cedars-Sinai, including world-renowned physician-scientists who seek a place where they can both conduct research and see patients--the ideal formula for discovery and its translation into cures. Our patients benefit from access to doctors at the top of their fields, and our researchers have an ideal community in which to study the impact of healthcare challenges, and reflect that knowledge in their research. The greater Los Angeles area in which Cedars-Sinai resides possesses unparalleled cultural and ethnic diversity which offers outstanding opportunities for translational and clinical research and a dynamic environment for medical education.Although community based, Cedars-Sinai is a major t...eaching hospital affiliated with the David Geffen School of Medicine at the University of California, Los Angeles (UCLA). Cedars-Sinai has highly competitive graduate medical education programs in more than 50 specialty and subspecialty areas, a graduate program in biomedical sciences and translational medicine, a clinical scholars program directed towards junior physicians with aspirations to become clinical scientists, and post graduate training opportunities.There are more than 250 full-time faculty members at Cedars-Sinai. The voluntary medical staff, comprised of more than 2,200 specialty board-certified or board-qualified physicians, represent all of the specialties and subspecialties and collaborate with full-time medical staff in the teaching responsibilities of the graduate medical education programs.