A cover letter is required for consideration for this position and should be attached as the first page of your resume. The cover letter should address your specific interest in the position and outline skills and experience that directly relate to this position.
We are looking for a lab technician to study transcriptional regulation of Notch-driven leukemia and early T-cell development at super-enhancers with a goal to develop the fundamental science needed to improve the effectiveness and safety of current cancer therapies and regenerative medicine. Lab website: http://chiangmarky8.wix.com/chiang-lab.
Specific methodologies: -Protein-protein interaction biochemistry (mass spectrometry; BIOID; NMR; co-IP; reverse-ChIP) -Leukemogenesis and T-cell development assays (flow cytometry sorting and analysis; histology; bone marrow transplantation; intrathymic injections; retroviral transduction and transplantation; in vitro stromal cell culture; transplantation in NSG mice) -Transcriptional genomics (ChIP-Seq/ATAC-Seq library preparation; computational analyses of RNA/ChIP/ATAC-sequencing data using existing pipelines; basic bioinformatics) -Transcription factor/enhancer assays (reporter; CRISPRi; ChIP; qRT-PCR)
Model systems: -Genetically engineered mouse models -Human leukemia patient-derived xenograft models -Human and mouse leukemia cell lines
Specific responsibilities: -Design, perform, analyze, and interpret experiments with training and supervision from PI and other lab members in line with skill set and with goal of independence -Work as a team with other lab members (PI, bioinformaticist, postdocs, PhD students, and the lab manager/work-study students) -Collaborate with members of other labs -If desired -- write manuscripts for publication, abstracts for research conferences, and present posters and talks
B.S. in biomedical field and 1+ years experience in a related field
Protein work, mouse models, transcription factor analysis
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Job openings are posted for a minimum of seven calendar days. The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled anytime after the minimum posting period has ended.
The University of Michigan is an equal opportunity/affirmative action employer.
Internal Number: 197002
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