Salary Range: Dependent upon experience & qualifications
**Lab website: http://wirkalab.com
We are seeking a highly-motivated, creative and collaborative Postdoctoral Research Associate to spearhead our efforts using human genetics to identify new mechanisms driving coronary artery disease (CAD). Starting with findings from genome-wide association studies (GWAS) of CAD, we identify the causal genes giving rise to these signals, study the effect of these genes on cellular and vessel wall biology, and finally determine the molecular pathways by which these genes influences CAD risk. To accomplish this, we knock out CAD genes in vivo in mouse models of atherosclerosis, perturb genes in vitro in human coronary artery cell lines, and utilize vascular samples from human patients. Within these model systems, we use single-cell transcriptomics and epigenomics, highly-multiplexed CRISPR perturbations, computational approaches, and traditional molecular biology techniques to identify the most critical pathways driving coronary disease.
Education and Experience:
Mastery of cell culture and traditional molecular biology techniques is required; experience with genetic mouse models and bioinformatics is also desirable. Preference will be given to candidates with a PhD or MD/PhD obtained within the last 3 years.
The University of North Carolina at Chapel Hill is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to age, color, disability, gender, gender expression, gender identity, genetic information, race, national origin, religion, sex, sexual orientation, or status as a protected veteran.
Carolina rates among the nation’s great institutions of higher education, set on an historic and beautiful campus that celebrates all four seasons. Carolina’s students, faculty and staff come here from around the world, bringing varied cultural, racial and ethnic heritages that help make UNC-Chapel Hill a thriving intellectual center. We’re repeatedly ranked the nation’s best value in higher education for students seeking to earn a college degree – the University has garnered the top spot each time since the ranking’s launch in 1998.Whether you’ve just started your career, are new to academia or are a seasoned professional with assorted campus experiences to draw on, we hope you will find a great place at Carolina.