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Bioinformatics Analyst II - Genomic Analysis Laboratory, Dr. Joseph Ecker
POSITION SUMMARY Large-scale-single-cell methylome profiling is the current state-of-art for studies that require the DNA methylation profiles at base resolution in heterogenous tissues. Single cell DNA methylation profiling offers the advantage of obtaining uniform genome wide coverage at cellular resolution. snmC-seq3 is an improved version of snmC-seq that provides better throughput, library complexity, coverage uniformity, and read mapping. This method is being used routinely in various projects including the DARPA-funded ECHO and MBA projects and several other projects for identifying DNA methylation patterns and their effects in samples such as blood cells and the brain. The Bioinformatics Analyst II will work closely with other members of the projec
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