Modeling the influence of advanced glycation end-products in aging and neurodegeneration using C. elegans and mice
The Kapahi Laboratory focuses on identifying and characterizing the mechanisms by which nutrients modulate aging and age-related diseases. This is being achieved by using an interdisciplinary approach combining genetic, pharmacological, biochemical and genomic approaches in invertebrate model systems C. elegans, D. melanogaster and mammalian cells. The broader significance of this research is to help uncover the role of nutrition in the etiology of age-related human diseases like diabetes, obesity and neurodegeneration.
The current position involves studying the role of glucose and Advanced Glycation Endproducts (AGEs) in aging and age-related diseases using C. elegans, mice and IPS derived cells.We propose to examine the mechanisms involved in synthesis and detoxification of Advanced Glycation Endproducts (AGEs).
Chaudhuri, J., Bose, N., Gong, J., Hall, D., Rifkind, A., Bhaumik, D., Peiris, T. H., Chamoli, M., Le, C. H., Liu, J., Lithgow, G. J., Ramanathan, A., Xu, X. Z. and Kapahi, P. "A Caenorhabditis elegans Model Elucidates a Conserved Role for TRPA1-Nrf Signaling in Reactive alpha-Dicarbonyl Detoxification." Curr Biol 26, no. 22 (2016): 3014-3025. PMC5135008
Zee, T., Bose, N., Zee, J., Beck, J. N., Yang, S., Parihar, J., Yang, M., Damodar, S., Hall, D., O'Leary, M. N., Ramanathan, A., Gerona, R. R., Killilea, D. W., Chi, T., Tischfield, J., Sahota, A., Kahn, A., Stoller, M. L. and Kapahi, P. "alpha-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria." Nat Med 23, no. 3 (2017): 288-290.
Katewa, S. D., Akagi, K., Bose, N., Rakshit, K., Camarella, T., Zheng, X., Hall, D., Davis, S., Nelson, C. S., Brem, R. B., Ramanathan, A., Sehgal, A., Giebultowicz, J. M. and Kapahi, P. "Peripheral Circadian Clocks Mediate Dietary Restriction-Dependent Changes in Lifespan and Fat Metabolism in Drosophila." Cell Metab 23, no. 1 (2016): 143-54. PMC4715572
Chen D, Melov S, Kapahi P. Germline Signaling Mediates the Synergistically Prolonged Longevity Produced by Double Mutations in daf-2 and rsks-1 in C. elegans. Cell Reports, 2013
RogersAN, Chen D, Czerwieniec G, McCollG, Felkey K, Melov S, GibsonB, HubbardA, LithgowGJ, Kapahi P. Post-transcriptional remodeling of longevity and stress response gene expression by inhibition of eIF-4G. Cell Metabolism, 2011
LIVING BETTER LONGER TOGETHER
Buck Institute for Research on Aging is an equal opportunity employer. Buck Institute seeks candidates whose experience and qualifications will enable them to contribute to our dedication to diversity and excellence. We are committed to building an organization that represents a variety of backgrounds, perspectives and skills. We welcome the unique contributions that you can bring in terms of education, opinions, culture, ethnicity, race, sex, gender identity and expression, nation of origin, age, languages spoken, veteran’s status, color, religion, disability, sexual orientation and beliefs.
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